Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics
文献类型：期刊论文
| 作者 | Keerthiga, Rajendiran1; Zhao, Zizhen1; Pei, Desheng2 ; Fu, Ailing1
|
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 6期号:10页码:5474-5485 |
| 关键词 | photodynamic therapy photosensitizer oncological therapeutics nanocarriers reactive oxygen species upconversion nanoparticles |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.0c01058 |
| 通讯作者 | Pei, Desheng(peids@cigit.ac.cn) ; Fu, Ailing(fal@swu.edu.cn) |
| 英文摘要 | Photodynamic theranostics/therapy (PDT) is a potential strategy for selectively imaging malignant sites and treating cancer via a non-invasive therapeutic method. Photosensitizers, the crucial components of PDT, enable colocalization of photons and light, and photon/light therapy in the therapeutic window of 400-900 nm exhibits photocytotoxicity to tumor cells. Due to their high biostability and photocytotoxicity, nanophotosensitizers (NPSs) are of much interest for malignant tumor theranostics at present. NPS-activated photons transfer energy through the absorption of a photon and convert molecular oxygen to the singlet reactive oxygen species, which leads to apoptosis and necrosis. Moreover, NPSs modified by polymers, including PLGA, PEG-PLA, PDLLA, PVCL-g-PLA, and P(VCL-co-VIM)-g-PLA, exhibit excellent biocompatibility, and a tumor-targeting molecule linked on the nanoparticle surface can precisely deliver NPSs into the tumor region. The development of NPSs will accelerate the progress in tumor theranostics through the photon/light pathway. |
| 资助项目 | Chongqing Research Program of Basic Research and Frontier Technology[cstc2018jcy-jAX0612] ; Chongqing Innovation Project for Returnees from Overseas Scholars in 2018[cx2018086] ; Chongqing Key Program of Basic Research and Advanced Exploration Project[cstc2019jcyj-zdxm0092] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000580903800007 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/12279]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Pei, Desheng; Fu, Ailing |
| 作者单位 | 1.Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Keerthiga, Rajendiran,Zhao, Zizhen,Pei, Desheng,et al. Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(10):5474-5485. |
| APA | Keerthiga, Rajendiran,Zhao, Zizhen,Pei, Desheng,&Fu, Ailing.(2020).Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(10),5474-5485. |
| MLA | Keerthiga, Rajendiran,et al."Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.10(2020):5474-5485. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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