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Applications of Photo-Responsive Molecules in Nanopore-based Devices

文献类型：期刊论文

作者Tang Jing1,2; Wang Sen1,2; Wu Ji1,2; Liang Li-Yuan1; Wang Liang1; Wang De-Qiang1
刊名CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
出版日期2020-11-01
卷号48期号:11页码:1458-1466
关键词Nanopores Light regulation Biosensors Photo-responsive molecules Structure switch Review
ISSN号0253-3820
DOI10.19756/j.issn.0253-3820.201247
通讯作者Liang Li-Yuan(liangliyuan@cigit.ac.cn) ; Wang De-Qiang(dqwang@cigit.ac.cn)
英文摘要In biochemistry, exploring the conformation, response to external environment and interaction rules of biomacromolecules and small molecules is crucial to understanding the correlation of structures and properties among organic matters. However, it is a challenge for the traditional techniques to observe the conformation heterogeneity and interpret the interaction mechanism of the biomolecules in living cells. As the emerged third generation single-molecule gene sequencing technology, nanopore can monitor the conformation change of the molecules in situ and therefore demonstrates good applications in single-molecule sensing and nucleic acid and protein sequencing. To further improve the detection resolution and precision, the combined photoelectric detection can achieve higher accuracy via introducing optical-responsive molecules. In view of the extensive applications and development status of nanopore technique in single-molecule conformation resolution, this paper summarizes the research progress of the nanopore devices and the design and applications of some typical photo-responsive molecules in nanopore sensing, including azobenzenes and their derivatives, spiropyrane and diarylethene. Light regulation is a simple and effective approach monitoring the molecular structures, and further integration with nanopore devices exhibits great potential in single-molecule detection meanwhile sheds light on the design and applications of multi-responsive nano-devices.
资助项目Natural Science Foundation of Chongqing, China[cstc2017jcyjB0105] ; Youth Innovation Promotion Association[2017392] ; University of Chinese Academy of Sciences
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000590139800004
出版者SCIENCE PRESS
源URL[http://119.78.100.138/handle/2HOD01W0/12303]  
专题中国科学院重庆绿色智能技术研究院
通讯作者Liang Li-Yuan; Wang De-Qiang
作者单位1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China
2.Univ Chinese Acad Sci, Chongqing Sch, Chongqing 400714, Peoples R China
推荐引用方式
GB/T 7714		 Tang Jing,Wang Sen,Wu Ji,et al. Applications of Photo-Responsive Molecules in Nanopore-based Devices[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2020,48(11):1458-1466.
APA Tang Jing,Wang Sen,Wu Ji,Liang Li-Yuan,Wang Liang,&Wang De-Qiang.(2020).Applications of Photo-Responsive Molecules in Nanopore-based Devices.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,48(11),1458-1466.
MLA Tang Jing,et al."Applications of Photo-Responsive Molecules in Nanopore-based Devices".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 48.11(2020):1458-1466.

入库方式： OAI收割

来源：重庆绿色智能技术研究院

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