Near-Field Nanoscopic Terahertz Imaging of Single Proteins
文献类型：期刊论文
| 作者 | Yang, Zhongbo2,3,4 ; Tang, Dongyun2,3,4; Hu, Jiao2,3,4; Tang, Mingjie2,3,4; Zhang, Mingkun2,3,4; Cui, Hong-Liang2,3; Wang, Lihua5; Chang, Chao1; Fan, Chunhai6,7; Li, Jiang5
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| 刊名 | SMALL
 |
| 出版日期 | 2020-12-11 |
| 页码 | 6 |
| ISSN号 | 1613-6810 |
| 关键词 | graphene HOPG near‐ field microscope single biomolecules terahertz |
| DOI | 10.1002/smll.202005814 |
| 通讯作者 | Li, Jiang(lijiang@zjlab.org.cn) ; Wang, Huabin(wanghuabin@cigit.ac.cn) |
| 英文摘要 | Terahertz (THz) biological imaging has attracted intense attention due to its capability of acquiring physicochemical information in a label-free, noninvasive, and nonionizing manner. However, extending THz imaging to the single-molecule level remains a challenge, partly due to the weak THz reflectivity of biomolecules with low dielectric constants. Here, the development of graphene-mediated THz scattering-type scanning near-field optical microscope for direct imaging of single proteins is reported. Importantly, it is found that a graphene substrate with high THz reflectivity and atomic flatness can provide high THz contrast against the protein molecules. In addition, a platinum probe with an optimized shaft length is found enabling the enhancement of the amplitude of the scattered THz near-field signals. By coupling these effects, the topographical and THz scattering images of individual immunoglobulin G (IgG) and ferritin molecules with the size of a few nanometers are obtained, simultaneously. The demonstrated strategy thus opens new routes to imaging single biomolecules with THz. |
| 资助项目 | National Key Research and Development Program of China[2017YFF0106303] ; National Natural Science Foundation of China[U1932132] ; National Natural Science Foundation of China[11604332] ; Natural Science Foundation of Chongqing[cstc2018jcyjAX0405] ; Natural Science Foundation of Chongqing[cstc2019jcyj-msxmX0654] ; Natural Science Foundation of Chongqing[cstc2019jcyj-msxmX0051] ; Shanghai Municipal Science and Technology Commission[19JC1410300] ; University of Chinese Academy of Sciences Supported Program for Tackling Key Problems in Science and Technology |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000597868700001 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/12605]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Li, Jiang; Wang, Huabin |
| 作者单位 | 1.Tsinghua Univ, Dept Engn Phys, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Res Ctr Appl Phys, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 3.Chongqing Engn Res Ctr High Resolut & Three Dimen, Chongqing 400714, Peoples R China 4.Univ Chinese Acad Sci, Chongqing Sch, Chongqing 400714, Peoples R China 5.Chinese Acad Sci, Shanghai Adv Res Inst, Bioimaging Ctr, Shanghai 201204, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China 7.Shanghai Jiao Tong Univ, Inst Mol Med, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Zhongbo,Tang, Dongyun,Hu, Jiao,et al. Near-Field Nanoscopic Terahertz Imaging of Single Proteins[J]. SMALL,2020:6. |
| APA | Yang, Zhongbo.,Tang, Dongyun.,Hu, Jiao.,Tang, Mingjie.,Zhang, Mingkun.,...&Wang, Huabin.(2020).Near-Field Nanoscopic Terahertz Imaging of Single Proteins.SMALL,6. |
| MLA | Yang, Zhongbo,et al."Near-Field Nanoscopic Terahertz Imaging of Single Proteins".SMALL (2020):6. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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