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Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta

文献类型：期刊论文

作者Huang, Zhenting1,2; Yan, Qian1,2,4; Wang, Yangyang1,2; Zou, Qian1,2; Li, Jing1,2; Liu, Zhou3; Cai, Zhiyou1,2
刊名JOURNAL OF ALZHEIMERS DISEASE
出版日期2020
卷号78期号:2页码:505-514
关键词Alzheimer's disease amyloid-beta dysfunction mitochondria pathology
ISSN号1387-2877
DOI10.3233/JAD-200519
通讯作者Liu, Zhou(liuzhou@gdmu.edu.cn) ; Cai, Zhiyou(caizhiyou@ucas.ac.cn)
英文摘要Mitochondrial dysfunction has been widely reported in several neurodegenerative disorders, including in the brains of patients with Alzheimer's disease (AD), Parkinson's disease, and Huntington disease. An increasing number of studies have implicated altered glucose and energy metabolism in patients with AD. There is compelling evidence of abnormalities in some of the key mitochondrial enzymes involved in glucose metabolism, including the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes, which play a great significance role in the pathogenesis of AD. Changes in some of the enzyme activities of the mitochondria found in AD have been linked with the pathology of amyloid-beta (A beta). This review highlights the role of mitochondrial function in the production and clearance of A beta and how the pathology of A beta leads to a decrease in energy metabolism by affecting mitochondrial function.
资助项目Chongqing Natural Science Foundation[cstc2018jc yjAX0602] ; Chongqing Health Commission[2018ZDXM004] ; Science and Technology Planning Project of Yuzhong District of Chongqing[20180104] ; Chongqing Health and Family Planning Scientific Research Project[ZY201702042]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000592248100002
出版者IOS PRESS
源URL[http://119.78.100.138/handle/2HOD01W0/12615]  
专题中国科学院重庆绿色智能技术研究院
通讯作者Liu, Zhou; Cai, Zhiyou
作者单位1.Chongqing Key Lab Neurodegenerat Dis, Chongqing, Peoples R China
2.Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, 312 Zhongshan First Rd, Chongqing 400013, Peoples R China
3.Guangdong Med Univ, Dept Neurol, Guangdong Key Lab Age Related Cardiac & Cerebral, Affiliated Hosp, Zhanjiang, Guangdong, Peoples R China
4.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Zhenting,Yan, Qian,Wang, Yangyang,et al. Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta[J]. JOURNAL OF ALZHEIMERS DISEASE,2020,78(2):505-514.
APA Huang, Zhenting.,Yan, Qian.,Wang, Yangyang.,Zou, Qian.,Li, Jing.,...&Cai, Zhiyou.(2020).Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta.JOURNAL OF ALZHEIMERS DISEASE,78(2),505-514.
MLA Huang, Zhenting,et al."Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta".JOURNAL OF ALZHEIMERS DISEASE 78.2(2020):505-514.

入库方式： OAI收割

来源：重庆绿色智能技术研究院

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