Ameliorating Ribosylation-Induced Amyloid-beta Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling
文献类型：期刊论文
| 作者 | Wang, Yang-Yang2,3; Yan, Qian1; Huang, Zhen-Ting2,3; Zou, Qian2,3; Li, Jing2,3; Yuan, Ming-Hao2,3; Wu, Liang-Qi1,4; Cai, Zhi-You2,3 |
| 刊名 | JOURNAL OF ALZHEIMERS DISEASE
 |
| 出版日期 | 2021 |
| 卷号 | 79期号:2页码:833-844 |
| 关键词 | AGEs Alzheimer's disease amyloid-beta autophagy berberine mTOR |
| ISSN号 | 1387-2877 |
| DOI | 10.3233/JAD-200995 |
| 通讯作者 | Wu, Liang-Qi(wulqi@ucas.ac.cn) ; Cai, Zhi-You(caizhiyou@ucas.ac.cn) |
| 英文摘要 | Background: Berberine (BBR) plays a neuroprotective role in the pathogenesis of Alzheimer's disease (AD), inhibiting amyloid-beta (A beta) production and promoting A beta clearance. Advanced glycation end products (AGEs) promote A beta aggregation and tau hyperphosphorylation. The activation of mTOR signaling occurring at the early stage of AD has a prominent impact on the A beta production. This work focused on whether BBR regulates the production and clearance of ribosylation-induced A beta pathology via inhibiting mTOR signaling. Objective: To explore whether BBR ameliorates ribosylation-induced A beta pathology in APP/PS1 mice. Methods: Western blot and immunofluorescence staining were used to detect the related proteins of the mammalian target of Rapamycin (mTOR) signaling pathway and autophagy, as well as the related kinases of A beta generation and clearance. Tissue sections and Immunofluorescence staining were used to observe A beta(42) in APP/PS1 mice hippocampal. Morris water maze test was used to measure the spatial learning and memory of APP/PS1 mice. Results: BBR improves spatial learning and memory of APP/PS1 mice. BBR limits the activation of mTOR/p70S6K signaling pathway and enhances autophagy process. BBR reduces the activity of BACE1 and y-secretase induced by D-ribose, and enhances A beta-degrading enzymes and Neprilysin, and inhibits the expression of A beta in APP/PS1 mice. Conclusion: BBR ameliorates ribosylation-induced A beta pathology via inhibiting mTOR/p70S6K signaling and improves spatial learning and memory of the APP/PS1 mice. |
| 资助项目 | Chongqing Natural Science Foundation[cstc2018jcyjAX0602] ; Science andTechnology Planning Project ofYuzhong District of Chongqing[20180104] ; Medical Science and Technology Innovation Fund project of Chongqing General Hospital[Y2018MSXM03] ; Chongqing Health and Family Planning Scientific Research Project[ZY201702042] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000611560100029 |
| 出版者 | IOS PRESS |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/12928]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Wu, Liang-Qi; Cai, Zhi-You |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, 266 Fangzheng Ave, Chongqing 400714, Peoples R China 2.Chongqing Key Lab Neurodegenerat Dis, Chongqing, Peoples R China 3.Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, 312 Zhongshan First Rd, Chongqing 400013, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yang-Yang,Yan, Qian,Huang, Zhen-Ting,et al. Ameliorating Ribosylation-Induced Amyloid-beta Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling[J]. JOURNAL OF ALZHEIMERS DISEASE,2021,79(2):833-844. |
| APA | Wang, Yang-Yang.,Yan, Qian.,Huang, Zhen-Ting.,Zou, Qian.,Li, Jing.,...&Cai, Zhi-You.(2021).Ameliorating Ribosylation-Induced Amyloid-beta Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling.JOURNAL OF ALZHEIMERS DISEASE,79(2),833-844. |
| MLA | Wang, Yang-Yang,et al."Ameliorating Ribosylation-Induced Amyloid-beta Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling".JOURNAL OF ALZHEIMERS DISEASE 79.2(2021):833-844. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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