Combined toxicity of endocrine-disrupting chemicals: A review
文献类型：期刊论文
| 作者 | Hamid, Naima1,2; Junaid, Muhammad2; Pei, De-Sheng1,2,3
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| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2021-06-01 |
| 卷号 | 215页码:14 |
| ISSN号 | 0147-6513 |
| 关键词 | Combined toxicity Endocrine disruption Predictive models Toxicogenomics |
| DOI | 10.1016/j.ecoenv.2021.112136 |
| 通讯作者 | Pei, De-Sheng(peids@cigit.ac.cn) |
| 英文摘要 | The combined toxicological assessment provides a realistic approach for hazard evaluation of chemical cocktails that co-existed in the environment. This review provides a holistic insight into the studies highlighting the mixture toxicity of the endocrine-disrupting chemicals (EDCs), especially focusing on the screening of biochemical pathways and other toxicogenetic endpoints. Reviewed literature showed that numerous multiplexed toxicogenomic techniques were applied to determine reproductive effects in vertebrates, but limited studies were found in non-mammalian species after mixture chemical exposure. Further, we found that the experimental design and concentration selection are the two important parameters in mixture toxicity studies that should be time- and cost-effective, highly precise, and environmentally relevant. A summary of EDC mixtures affecting the thyroid axis, estrogen axis, androgen axis, growth stress, and immune system via in vivo bioassays was also presented. It is interesting to mention that majority of estrogenic effects of the mixtures were sex-dependent, particularly observed in male fish as compared to female fish. Further, the androgen axis was perturbed with serious malformations in male rat testis (epididymal or gubernacular lesions, and deciduous spermatids). Also, transgenerational epigenetic effects were promoted in the F3 and F4 generations in the form of DNA methylation epimutations in sperm, increasing polycystic ovaries and reducing the offspring. Similarly, increased oxidative stress, high antioxidant enzymatic activities, disturbed estrous cycle, and decreased steroidogenesis were the commonly found effects after acute or chronic exposure to EDC mixtures. Importantly, the concentration addition (CA) and independent action (IA) models became more prevalent and suitable predictive models to unveil the prominence of synergistic estrogenic and anti-androgenic effects of chemical mixtures. More importantly, this review encompasses the research challenges and gaps in the existing knowledge and specific future research perspectives on combined toxicity. |
| 资助项目 | CAS Team Project of the Belt and Road ; Chongqing Key Program of Basic Research and Advanced Exploration Project[cstc2019jcyj-zdxmX0035] ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; CAS-TWAS Scholarship[2017A8018537001] ; Program of China-Sri Lanka Joint Center for Water Technology Research and Demonstration by Chinese Academy of Sciences (CAS)/China-Sri Lanka Joint Center for Education and Research by CAS ; International Partnership Program of CAS[121311kysb20190071] |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000637943500007 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/13320]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Pei, De-Sheng |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 3.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hamid, Naima,Junaid, Muhammad,Pei, De-Sheng. Combined toxicity of endocrine-disrupting chemicals: A review[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,215:14. |
| APA | Hamid, Naima,Junaid, Muhammad,&Pei, De-Sheng.(2021).Combined toxicity of endocrine-disrupting chemicals: A review.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,215,14. |
| MLA | Hamid, Naima,et al."Combined toxicity of endocrine-disrupting chemicals: A review".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 215(2021):14. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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