Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes
文献类型：期刊论文
| 作者 | Yang, Xiaohong1,2; Xie, Beibei2; Peng, Haibo2; Shi, Gongming2; Sreenivas, Banne2; Guo, Jian2; Wang, Chenhui2; He, Yun2 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2021-01-10 |
| 卷号 | 329页码:454-467 |
| 关键词 | Exosomes Surface functionalization Antibiotics Targeted delivery Intracellular infection |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2020.11.045 |
| 通讯作者 | Wang, Chenhui(wangchenhui@cqu.edu.cn) ; He, Yun(yun.he@cqu.edu.cn) |
| 英文摘要 | Intracellular methicillin-resistant Staphylococcus aureus (MRSA) is extremely difficult to remove by common antibiotics, leading to infection recurrence and resistance. Herein we report a novel exosome-based antibiotic delivery platform for eradicating intracellular MRSA, where mannosylated exosome (MExos) is employed as the drug carrier and preferentially taken up by macrophages, delivering lysostaphin (MExoL) and vancomycin (MExoV) to intracellular pathogens. Combination of MExoL and MExoV eradicated intracellular quiescent MRSA. Moreover, MExos rapidly accumulated in mouse liver and spleen, the target organs of intracellular MRSA, after intravenous (IV) administration. Thus, the MExos antibiotic delivery platform is a promising strategy for combating intracellular infection. |
| 资助项目 | National Natural Science Foundation of China[21572027] ; National Natural Science Foundation of China[81703424] ; Ministry of Science and Technology[2019ZX09301164] ; Chongqing Science and Technology Bureau[csts2019jcyj-zdxmX0021] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000626334700033 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/13329]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Wang, Chenhui; He, Yun |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, 266 Fangzheng Ave,Shuitu Technol Dev Zone, Chongqing 400714, Peoples R China 2.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaohong,Xie, Beibei,Peng, Haibo,et al. Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes[J]. JOURNAL OF CONTROLLED RELEASE,2021,329:454-467. |
| APA | Yang, Xiaohong.,Xie, Beibei.,Peng, Haibo.,Shi, Gongming.,Sreenivas, Banne.,...&He, Yun.(2021).Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes.JOURNAL OF CONTROLLED RELEASE,329,454-467. |
| MLA | Yang, Xiaohong,et al."Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes".JOURNAL OF CONTROLLED RELEASE 329(2021):454-467. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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