Chronic exposure to PPCPs mixture at environmentally relevant concentrations (ERCs) altered carbohydrate and lipid metabolism through gut and liver toxicity in zebrafish
文献类型：期刊论文
| 作者 | Hamid, Naima1,3; Junaid, Muhammad1; Wang, Yan1,3; Pu, Shi-Ya1,3; Jia, Pan-Pan1; Pei, De-Sheng1,2,3
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| 刊名 | ENVIRONMENTAL POLLUTION
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| 出版日期 | 2021-03-15 |
| 卷号 | 273页码:10 |
| 关键词 | Hepatotoxicity Gut homeostasis Chronic exposure Lipid metabolism Zebrafish |
| ISSN号 | 0269-7491 |
| DOI | 10.1016/j.envpol.2021.116494 |
| 通讯作者 | Pei, De-Sheng(peids@cigit.ac.cn) |
| 英文摘要 | Pharmaceuticals and personal care products (PPCPs) have been widely distributed and posed ecotoxicological risks in the aquatic environment. This study aims to evaluate the toxic effects after chronic exposure to PPCPs mixture at the environment relevant concentrations (ERCs). Our results indicated that PPCPs induced serious metabolic effects by disturbing the carbohydrate and lipid metabolism pathways. Chronic exposure caused a significant reduction in the hepatosomatic index (HSI), the gut weight ratios, and histological alterations in liver and gut tissues. Further, exposure to the combined PPCPs disrupted the carbohydrate metabolism via significant upregulation of hk1, gk, pck1, and insr genes. The lipid metabolism was affected with higher ppars expression levels that increased the fatty acid beta-oxidation and ultimately decreased the lipidogenesis. Moreover, the altered responses of the insulin growth factor (IGF) pathway more in male gut tissue than that of female revealed sex-dependent disturbance in the gut homeostasis induced by PPCPs mixture. In conclusion, chronic exposure to PPCPs mixtures at ERCs can induce developmental effects and metabolic dysfunction in both male and female fish. The consumption and environmental disposal of these PPCPs should be regulated to ensure ecological health and environmental safety. (C) 2021 Elsevier Ltd. All rights reserved. |
| 资助项目 | CAS Team Project of the Belt and Road ; Chongqing Key Program of Basic Research and Advanced Exploration Project[cstc2019jcyjzdxmX0035] ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; CAS-TWAS Scholarship[2017A8018537001] ; International Partnership Program of CAS[121311kysb20190071] ; Program of China-Sri Lanka Joint Center for Water Technology Research and Demonstration by the Chinese Academy of Sciences (CAS)/Chinae-Sri Lanka Joint Center for Education and Research by the CAS |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000625376600073 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/13344]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Pei, De-Sheng |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Reservoir Aquat Environm, Chongqing 400714, Peoples R China 2.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hamid, Naima,Junaid, Muhammad,Wang, Yan,et al. Chronic exposure to PPCPs mixture at environmentally relevant concentrations (ERCs) altered carbohydrate and lipid metabolism through gut and liver toxicity in zebrafish[J]. ENVIRONMENTAL POLLUTION,2021,273:10. |
| APA | Hamid, Naima,Junaid, Muhammad,Wang, Yan,Pu, Shi-Ya,Jia, Pan-Pan,&Pei, De-Sheng.(2021).Chronic exposure to PPCPs mixture at environmentally relevant concentrations (ERCs) altered carbohydrate and lipid metabolism through gut and liver toxicity in zebrafish.ENVIRONMENTAL POLLUTION,273,10. |
| MLA | Hamid, Naima,et al."Chronic exposure to PPCPs mixture at environmentally relevant concentrations (ERCs) altered carbohydrate and lipid metabolism through gut and liver toxicity in zebrafish".ENVIRONMENTAL POLLUTION 273(2021):10. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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