Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish*
文献类型：期刊论文
| 作者 | Jia, Pan-Pan1; Junaid, Muhammad1; Wen, Ping-Ping1,2; Yang, Yi-Fan1,2; Li, Wei-Guo2; Yang, Xian-Guang2; Pei, De-Sheng1,2
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| 刊名 | ENVIRONMENTAL POLLUTION
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| 出版日期 | 2021-06-15 |
| 卷号 | 279页码:14 |
| ISSN号 | 0269-7491 |
| 关键词 | Gut microbial functions Germ-free zebrafish model Host diseases Probiotic therapy |
| DOI | 10.1016/j.envpol.2021.116925 |
| 通讯作者 | Pei, De-Sheng(peids@cigit.ac.cn) |
| 英文摘要 | Numerous pieces of evidence documented the importance of gut microbiota in regulating human health and evaluating the toxicity of environmental pollutants, which are closely related to the host health in various aspects, including nutrition, energy translation, metabolism, pathogen resistance, and immune function. A variety of environmental factors can disrupt gut microbiota and their functions, and inevitably cause immune diseases, obesity and diabetes. However, deciphering the inner mechanisms involved in the functional interaction of gut microbes with host health is still needed extensive investigations. This review focused on the essential roles of intestinal microbes in host-related diseases and highlighted the development and applications of germ-free (GF) animal models, mainly zebrafish. Moreover, the generation, immunity characters, advantages and challenges of GF zebrafish models were also summarized. Importantly, the composition and isolation of zebrafish gut bacteria for further application and toxicity evaluation of aquatic environmental pollutants were also discussed. In conclusion, GF zebrafish play irreplaceable roles in understanding the potential functions and responses of customized microbiota towards human and environmental health implications. 0 2021 Elsevier Ltd. All rights reserved. |
| 资助项目 | CAS Team Project of the Belt and Road ; Youth Innovation Program of Chongqing Institute of Green and Intelligent Technology, CAS[Y83A160S10] ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; Program of China-Sri Lanka Joint Center for Water Technology Research and Demonstration by Chinese Academy of Sciences (CAS)/China-Sri Lanka Joint Center for Education and Research by CAS ; International Partnership Program of CAS[121311kysb20190071] ; Chongqing Key Program of Basic Research and Advanced Exploration Project[cstc2019jcyj-zdxmX0035] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000647790400005 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/13550]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Pei, De-Sheng |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 2.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Pan-Pan,Junaid, Muhammad,Wen, Ping-Ping,et al. Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish*[J]. ENVIRONMENTAL POLLUTION,2021,279:14. |
| APA | Jia, Pan-Pan.,Junaid, Muhammad.,Wen, Ping-Ping.,Yang, Yi-Fan.,Li, Wei-Guo.,...&Pei, De-Sheng.(2021).Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish*.ENVIRONMENTAL POLLUTION,279,14. |
| MLA | Jia, Pan-Pan,et al."Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish*".ENVIRONMENTAL POLLUTION 279(2021):14. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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