PEGylated copper(II)-chelated polydopamine nanocomposites for photothermal-enhanced chemodynamic therapy against tumor cells
文献类型：期刊论文
| 作者 | Zhang, Qiuye3; Wang, Jingjing1,3; Xu, Luen3; Lu, Shi-Yu1,3; Yang, Huawei1; Duan, Yifan3; Yang, Qiang3; Qiu, Mengfan3; Chen, Chunmei3; Zhao, Sheng3 |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2021-05-22 |
| 页码 | 9 |
| 关键词 | biomaterials nanostructured polymers thermal properties self‐ assembly |
| ISSN号 | 0021-8995 |
| DOI | 10.1002/app.51172 |
| 通讯作者 | Liu, Xiaohong(lxhsuda@163.com) ; Liu, Hui(liuhui2016@swu.edu.cn) |
| 英文摘要 | Photothermal-enhanced chemodynamic therapy is a novel and promising strategy for effective tumor treatment. Herein, a kind of polydopamine (PDA)-based nanoplatform is reported for photothermal-enhanced chemodynamic therapy against tumor cells. PDA nanoparticles (NPs) were prepared through the self-polymerization method, which were subsequently chelated with Cu2+ and linked with poly(ethylene glycol) (PEG) chains, finally obtaining PDA-Cu(II)-PEG NPs. The fabricated PDA-Cu(II)-PEG NPs were uniform in shape with a narrow polydispersity. They can firstly react with glutathione (GSH) to generate Cu+, inducing GSH depletion meanwhile. The formed Cu+ could catalyze H2O2 to produce hydroxyl radicals (OH) via a Fenton-like reaction. The formed PDA-Cu(II)-PEG NPs displayed good photothermal conversion efficiency and photothermal stability. They can be internalized by 4T1 cells effectively. Under near-infrared light irradiation, PDA-Cu(II)-PEG NPs can generate hyperthermia and OH for photothermal/chemodynamic therapy against tumor cells. |
| 资助项目 | National Natural Science Foundation of China[51703184] ; Fundamental Research Funds for the Central Universities from Southwest University[XDJK2018B007] ; Natural Science Foundation of Chongqing[cstc2019jcyj-msxmX0663] ; science and technology research program of Chongqing Municipal Education Commission[KJQN201904102] ; science and technology research program of Chongqing Municipal Education Commission[KJQN202004104] ; Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices and Innovation Teams in Colleges and Universities of Chongqing[CXQT20005] |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000652834800001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/13649]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Liu, Xiaohong; Liu, Hui |
| 作者单位 | 1.Peking Univ, Beijing Innovat Ctr Engn Sci & Adv Technol, Beijing Key Lab Magnetoelect Mat & Devices, Dept Mat Sci & Engn,Coll Engn, Beijing, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China 3.Southwest Univ, Sch Mat & Energy, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing 400715, Peoples R China 4.Chongqing Youth Vocat & Tech Coll, Chongqing 400712, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Qiuye,Wang, Jingjing,Xu, Luen,et al. PEGylated copper(II)-chelated polydopamine nanocomposites for photothermal-enhanced chemodynamic therapy against tumor cells[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2021:9. |
| APA | Zhang, Qiuye.,Wang, Jingjing.,Xu, Luen.,Lu, Shi-Yu.,Yang, Huawei.,...&Liu, Hui.(2021).PEGylated copper(II)-chelated polydopamine nanocomposites for photothermal-enhanced chemodynamic therapy against tumor cells.JOURNAL OF APPLIED POLYMER SCIENCE,9. |
| MLA | Zhang, Qiuye,et al."PEGylated copper(II)-chelated polydopamine nanocomposites for photothermal-enhanced chemodynamic therapy against tumor cells".JOURNAL OF APPLIED POLYMER SCIENCE (2021):9. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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