Essential role of the endocytic site-associated protein Ecm25 in stress-induced cell elongation
文献类型：期刊论文
| 作者 | Duan, Xudong1,3,4; Chen, Xi3; Wang, Kangji3; Chen, Li3; Glomb, Oliver2; Johnsson, Nils2; Feng, Lin1; Zhou, Xiao-Qiu1; Bi, Erfei3 |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2021-05-18 |
| 卷号 | 35期号:7页码:24 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2021.109122 |
| 通讯作者 | Zhou, Xiao-Qiu(zhouxq@sicau.edu.cn) ; Bi, Erfei(ebi@pennmedicine.upenn.edu) |
| 英文摘要 | Howcells adopt a different morphology to cope with stress is not well understood. Here, weshow that budding yeast Ecm25 associates with polarized endocytic sites and interacts with the polarity regulator Cdc42 and several late-stage endocytic proteins via distinct regions, including an actin filament-binding motif. Deletion of ECM25 does not affect Cdc42 activity or cause any strong defects in fluid-phase and clathrin-mediated endocytosis but completely abolishes hydroxyurea-induced cell elongation. This phenotype is accompanied by depolarization of the spatiotemporally coupled exo-endocytosis in the bud cortex while maintaining the overall mother-bud polarity. These data suggest that Ecm25 provides an essential link between the polarization signal and the endocytic machinery to enable adaptive morphogenesis under stress conditions. |
| 资助项目 | National Institutes of Health[GM116876] ; China Scholarship Council ; National Key R&D Program of China[2018YFD0900400] ; National Natural Science Foundation of China[31772866] ; Deutsche Forschungsgesellschaft (DFG)[JO 187/8-1] ; Deutsche Forschungsgesellschaft (DFG)[JO187/5-2] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000653685900001 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/13670]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Zhou, Xiao-Qiu; Bi, Erfei |
| 作者单位 | 1.Sichuan Agr Univ, Anim Nutr Inst, Chengdu 611130, Sichuan, Peoples R China 2.Univ Ulm, Inst Mol Genet & Zellbiol, D-89081 Ulm, Germany 3.Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA 4.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Xudong,Chen, Xi,Wang, Kangji,et al. Essential role of the endocytic site-associated protein Ecm25 in stress-induced cell elongation[J]. CELL REPORTS,2021,35(7):24. |
| APA | Duan, Xudong.,Chen, Xi.,Wang, Kangji.,Chen, Li.,Glomb, Oliver.,...&Bi, Erfei.(2021).Essential role of the endocytic site-associated protein Ecm25 in stress-induced cell elongation.CELL REPORTS,35(7),24. |
| MLA | Duan, Xudong,et al."Essential role of the endocytic site-associated protein Ecm25 in stress-induced cell elongation".CELL REPORTS 35.7(2021):24. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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