Enzyme inspired polymer functionalized with an artificial catalytic triad
文献类型：期刊论文
| 作者 | Bhaskaran, Ayana1; Aitken, Heather M.1; Xiao, Zeyun2,3 ; Blyth, Mitchell1; Nothling, Mitchell D.3; Kamdar, Shashank3; O'Mara, Megan L.1; Connal, Luke A.1
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| 刊名 | POLYMER
 |
| 出版日期 | 2021-05-26 |
| 卷号 | 225页码:5 |
| ISSN号 | 0032-3861 |
| 关键词 | Enzyme mimic Bioinspired Catalyst |
| DOI | 10.1016/j.polymer.2021.123735 |
| 通讯作者 | Connal, Luke A.(Luke.connal@anu.edu.au) |
| 英文摘要 | At the heart of an enzyme's structure is the active catalytic site, which, together with the surrounding amino-acid residues, tunes the substrate properties in the electrostatic microenvironment. Taking inspiration from nature's catalytic triad, consisting of a hydroxyl group of a serine residue, an imidazole group of a histidine residue, and a carboxyl group of an aspartic acid, a polymer scaffolded enzyme mimic is incorporated with artificial catalytic triad units. It is demonstrated that controlling the local environment of the artificial triad affects catalytic activity. Compared to a water soluble artificial catalytic triad, enhanced esterolytic activity of p-nitrophenyl benzoate was observed for the polymeric catalyst possibly due to the hydrophobic microenvironment formed by the tertiary structure of the polymer backbone. The different environments were supported by molecular dynamics simulations. It is further demonstrated that the cross-linked catalytic triad functional polystyrene could be used as a reusable solid support catalyst for esterolysis. |
| 资助项目 | U.S. Army International Technology Centre Pacific ITC-PAC[FA5209-14-C-0017] ; Australian Research Council (ARC)[DP200100535] |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000651460700007 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/13688]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Connal, Luke A. |
| 作者单位 | 1.Australian Natl Univ, Res Sch Chem, Canberra, ACT 2600, Australia 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 3.Univ Melbourne, Dept Chem & Biomol Engn, Melbourne, Vic 3010, Australia |
| 推荐引用方式 GB/T 7714 | Bhaskaran, Ayana,Aitken, Heather M.,Xiao, Zeyun,et al. Enzyme inspired polymer functionalized with an artificial catalytic triad[J]. POLYMER,2021,225:5. |
| APA | Bhaskaran, Ayana.,Aitken, Heather M..,Xiao, Zeyun.,Blyth, Mitchell.,Nothling, Mitchell D..,...&Connal, Luke A..(2021).Enzyme inspired polymer functionalized with an artificial catalytic triad.POLYMER,225,5. |
| MLA | Bhaskaran, Ayana,et al."Enzyme inspired polymer functionalized with an artificial catalytic triad".POLYMER 225(2021):5. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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