Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1 alpha/VEGF signalling pathway
文献类型：期刊论文
| 作者 | Wang, Rui1,2; Zhang, Ziyue2; Xu, Zaicheng2; Wang, Na2; Yang, Dezhong2; Liu, Zhi Zhao3; Liao, Qiao2; Xia, Xuewei2; Chen, Caiyu2; Shou, Jialing2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2021-08-04 |
| 卷号 | 11期号:1页码:10 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-021-95110-7 |
| 通讯作者 | Xia, Tianyang(Xia_ty@126.com) ; Wang, Hongyong(whysir@aliyun.com) |
| 英文摘要 | Acute myocardial infarction (MI) is one of the leading causes of death in humans. Our previous studies showed that gastrin alleviated acute myocardial ischaemia-reperfusion injury. We hypothesize that gastrin might protect against heart injury after MI by promoting angiogenesis. An MI model was simulated by ligating the anterior descending coronary artery in adult male C57BL/6J mice. Gastrin was administered twice daily by intraperitoneal injection for 2 weeks after MI. We found that gastrin reduced mortality, improved myocardial function with reduced infarct size and promoted angiogenesis. Gastrin increased HIF-1 alpha and VEGF expression. Downregulation of HIF-1 alpha expression by siRNA reduced the proliferation, migration and tube formation of human umbilical vein endothelial cells. These results indicate that gastrin restores cardiac function after MI by promoting angiogenesis via the HIF-1 alpha /VEGF pathway. |
| 资助项目 | National Natural Science Foundation of China[81930008] ; National Key R&D Program of China[2018YFC1312700] ; Program of Innovative Research Team by National Natural Science Foundation[81721001] ; Program for Changjiang Scholars and Innovative Research Team in University[IRT1216] ; Key Project of Chongqing Fundamental Science and Frontier Technology Research[cstc2015jcyjBX0129] ; Project of Chongqing Technology Innovation and Application Demonstration Special Social and People's Livelihood Key Research and Development[cstc2018jscx-mszd0082] ; Clinical Technology Innovation and Cultivation Program of AMU[CX2019JS220] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PORTFOLIO |
| WOS记录号 | WOS:000684831900009 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/13918]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Xia, Tianyang; Wang, Hongyong |
| 作者单位 | 1.Third Mil Med Univ, Army Hlth Serv Training Base, Dept Mil Med Geog, Chongqing 400038, Peoples R China 2.Third Mil Med Univ, Daping Hosp, Chongqing Inst Cardiol, Dept Cardiol, Chongqing 400042, Peoples R China 3.Chongqing Inst Green & Intelligent Technol, Inst Hlth Biol Chem Medicat, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Rui,Zhang, Ziyue,Xu, Zaicheng,et al. Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1 alpha/VEGF signalling pathway[J]. SCIENTIFIC REPORTS,2021,11(1):10. |
| APA | Wang, Rui.,Zhang, Ziyue.,Xu, Zaicheng.,Wang, Na.,Yang, Dezhong.,...&Wang, Hongyong.(2021).Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1 alpha/VEGF signalling pathway.SCIENTIFIC REPORTS,11(1),10. |
| MLA | Wang, Rui,et al."Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1 alpha/VEGF signalling pathway".SCIENTIFIC REPORTS 11.1(2021):10. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。