Cross Disjoint Mortise Confined Solid-State Nanopores for Single-Molecule Detection
文献类型：期刊论文
| 作者 | Liu, Yexiang1,2; Zhang, Xiaoling1,2; Xie, Wanyi1,2 ; Fang, Shaoxi1,2; Yin, Bohua1,2; Zhou, Daming1,2; Tang, Jing1,2; Liang, Liyuan1,2; Lu, Wenqiang1,2; He, Shixuan1,2
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| 刊名 | ACS APPLIED NANO MATERIALS
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| 出版日期 | 2021-09-24 |
| 卷号 | 4期号:9页码:9811-9820 |
| 关键词 | solid-state nanopore controlled dielectric breakdown cross disjoint mortise structure CDM-Nanopore confined domain |
| ISSN号 | 2574-0970 |
| DOI | 10.1021/acsanm.1c02227 |
| 通讯作者 | He, Shixuan(heshixuan@cigit.ac.cn) ; Wang, Deqiang(dqwang@cigit.ac.cn) |
| 英文摘要 | Solid-state nanopores have attracted widespread attention in the single-molecule detection application. However, getting controllable nanopores with high sensitivity and robustness requires a revolutionary breakthrough in nanopore fabrication. As a convenient and low-cost nanopore fabrication method, the controlled dielectric breakdown technology can hardly control the position and number of nanopores. This work proposes a concept of cross disjoint mortise confined solid-state nanopore (CDM-Nanopore) fabricated using a focused gallium ion beam and controlled dielectric breakdown technologies. A confined domain formed by the two cross disjoint mortise structures localizes the position for nanopore fabrication with a controlled dielectric breakdown method. The ion translocation analyses and noise performance of CDM-Nanopore were experimentally demonstrated with excellent sensitivities for long-term molecular detection due to their robustness and low noise characteristics of cross disjoint mortise structures. The surface charges have a great effect on the capture rate for DNA translocation in the confined nanopore while adding the formamide into G-quadruplex translocation experimentally. Besides, the COMSOL simulation results verify that the CDM-Nanopore has the same electrical properties as the conventional nanopore with the same effective thickness. These provide insight into an understanding of DNA translocation in the CDM-Nanopore to enable the localized nanopore fabrication with the controlled dielectric breakdown technology. Our results can be used to expand the membrane nanopores to zero-depth nanopores for molecular sensing and DNA/RNA sequencing. |
| 资助项目 | Youth Innovation Foundation of CIGIT ; Natural Science Foundation of Chongqing, China[cstc2018jcyjAX0310] ; Natural Science Foundation of Chongqing, China[cstc2018jcyjAX0308] ; National Natural Science Foundation of China[61701474] ; National Natural Science Foundation of China[31800711] ; Instrument Development Program of Chinese Academy of Sciences[YZ201568] ; Excellent Youth Foundation of Chongqing Scientific Committee[cstc2021jcyj-jq0013] ; West Light Foundation of the Chinese Academy of Sciences |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000702079900116 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/14102]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | He, Shixuan; Wang, Deqiang |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 2.Univ Chinese Acad Sci, Chongqing Sch, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yexiang,Zhang, Xiaoling,Xie, Wanyi,et al. Cross Disjoint Mortise Confined Solid-State Nanopores for Single-Molecule Detection[J]. ACS APPLIED NANO MATERIALS,2021,4(9):9811-9820. |
| APA | Liu, Yexiang.,Zhang, Xiaoling.,Xie, Wanyi.,Fang, Shaoxi.,Yin, Bohua.,...&Wang, Deqiang.(2021).Cross Disjoint Mortise Confined Solid-State Nanopores for Single-Molecule Detection.ACS APPLIED NANO MATERIALS,4(9),9811-9820. |
| MLA | Liu, Yexiang,et al."Cross Disjoint Mortise Confined Solid-State Nanopores for Single-Molecule Detection".ACS APPLIED NANO MATERIALS 4.9(2021):9811-9820. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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