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Single nucleotide discrimination with sub-two nanometer monolayer graphene pore

文献类型：期刊论文

作者Zhang, Zi-Yin2; Cui, Hong-Liang1,2; Huang, De-Ping2; Wang, De-Qiang2
刊名SENSORS AND ACTUATORS B-CHEMICAL
出版日期2021-12-15
卷号349页码:10
关键词Monolayer graphene Solid-state nanopore Helium ion milling Single nucleotide
DOI10.1016/j.snb.2021.130792
通讯作者Cui, Hong-Liang(hcui@jlu.edu.cn) ; Wang, De-Qiang(dqwang@cigit.ac.cn)
英文摘要The effective sensing area is the key point of solid-state nanopore single-molecule detection, which is determined by the diameter of the hole and the thickness of the membrane. High spatial resolution can be achieved by using single-atom thickness two-dimensional materials, such as single-layer graphene and molybdenum disulfide. Helium ion beam microscopy provides an effective technique for manufacturing small-sized nanopores. Here, we show that the precise fabrication of sub-2 nanometer nanopores has been successfully achieved on a single-layer graphene film, which provides the best spatial resolution in room-temperature ionic liquid-assisted singlemolecule detection. Many graphene nanopores of different sizes have been fabricated, with a minimum pore diameter of 1.4 nm. The application of these graphene nanopores manufactured by HIM shows that single-layer graphene nanopores can distinguish different homopolymer single-stranded DNA lengths and types, and can even identify four single nucleotides.
资助项目Natural Sci-ence Foundation of Chongqing, China[cstc2018jcyjAX0310] ; Natural Sci-ence Foundation of Chongqing, China[cstc2017jcyjB0105] ; Natural Sci-ence Foundation of Chongqing, China[cstc2018jcyjAX0304] ; National Natural Science Foundation of China[61701474] ; National Natural Science Foundation of China[31800711] ; Instrument development program of the Chinese Academy of Sciences[YZ201568] ; Pioneer Hundred Talents Program of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017392]
WOS研究方向Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种英语
WOS记录号WOS:000707315100002
出版者ELSEVIER SCIENCE SA
源URL[http://119.78.100.138/handle/2HOD01W0/14321]  
专题中国科学院重庆绿色智能技术研究院
通讯作者Cui, Hong-Liang; Wang, De-Qiang
作者单位1.Jilin Univ, Coll Instrumentat & Elect Engn, Changchun 130061, Jilin, Peoples R China
2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zi-Yin,Cui, Hong-Liang,Huang, De-Ping,et al. Single nucleotide discrimination with sub-two nanometer monolayer graphene pore[J]. SENSORS AND ACTUATORS B-CHEMICAL,2021,349:10.
APA Zhang, Zi-Yin,Cui, Hong-Liang,Huang, De-Ping,&Wang, De-Qiang.(2021).Single nucleotide discrimination with sub-two nanometer monolayer graphene pore.SENSORS AND ACTUATORS B-CHEMICAL,349,10.
MLA Zhang, Zi-Yin,et al."Single nucleotide discrimination with sub-two nanometer monolayer graphene pore".SENSORS AND ACTUATORS B-CHEMICAL 349(2021):10.

入库方式： OAI收割

来源：重庆绿色智能技术研究院

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