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Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array

文献类型：期刊论文

作者Fan, Sisi5; Ji, Bin5; Liu, Yan5; Zou, Kexuan5; Tian, Zhijin1,4; Dai, Bin5; Cui, Daxiang5; Zhang, Pengfei1; Ke, Yonggang2,3; Song, Jie1,5
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期2022-01-11
关键词cascade reactions dynamic regulation reconfigurable DNA origami spatial control
ISSN号1433-7851
DOI10.1002/anie.202116324
通讯作者Song, Jie(sjie@sjtu.edu.cn)
英文摘要Inspired by efficient biomolecular reactions in the cell, versatile DNA nanostructures have been explored for manipulating the spatial position and regulating reactions at the molecular level. Spatially controlled arrangement of molecules on the artificial scaffolds generally leads to enhanced reaction activities. Especially, the rich toolset of dynamic DNA nanostructures provides a potential route towards more sophisticated and vigorous regulation of molecular reactions. Herein, a reconfigurable DNA origami domino array (DODA) as a dynamic scaffold was adopted in this work for temporal-controlled and switchable molecular cascade reactions. Dynamic regulation of the assembly of G-quadruplex, hybridization of parallel-stranded duplex and assembly of binary DNAzyme were demonstrated. Molecular cascade reactions on the triggered reconfiguration of DODAs were realized, resulting in more complex, dynamic, and switchable control over the reactions.
WOS关键词NANOROBOT
资助项目National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[22161132008] ; Natural Science Foundation of Shanghai, China[19520714100] ; Natural Science Foundation of Shanghai, China[19ZR1475800] ; Project of Shanghai Jiao Tong University[2019QYA03] ; Project of Shanghai Jiao Tong University[YG2017ZD07] ; Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study[SN-ZJU-SIAS-006] ; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences ; Zhiyuan Innovative Research Center, SJTU
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000741469700001
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Shanghai, China ; Project of Shanghai Jiao Tong University ; Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study ; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences ; Zhiyuan Innovative Research Center, SJTU
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/127097]  
专题中国科学院合肥物质科学研究院
通讯作者Song, Jie
作者单位1.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Canc Hosp, Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China
2.Emory Univ, Atlanta, GA 30322 USA
3.Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA
4.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
5.Shanghai Jiao Tong Univ, Inst Nano Biomed & Engn, Dept Instrument Sci & Engn, Sch Elect Informat & Elect Engn, Shanghai 200240, Peoples R China
推荐引用方式
GB/T 7714		 Fan, Sisi,Ji, Bin,Liu, Yan,et al. Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022.
APA Fan, Sisi.,Ji, Bin.,Liu, Yan.,Zou, Kexuan.,Tian, Zhijin.,...&Song, Jie.(2022).Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA Fan, Sisi,et al."Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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