CD71-Specific Aptamer Conjugated with Monomethyl Auristatin E for the Treatment of Uveal Melanoma
文献类型：期刊论文
| 作者 | Zhang, Hui1,2 ; Jin, Cheng2; Zhang, Lin2; Peng, Bo2; Zhang, Yibin2; Liu, Yan2; Li, Ling2; Ye, Mao2; Xiong, Wei; Tan, Weihong1,2
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2021-12-20 |
| ISSN号 | 1944-8244 |
| 关键词 | uveal melanoma CD71 aptamer-drug conjugate targeted drug delivery tumor-targeted therapy |
| DOI | 10.1021/acsami.1c13980 |
| 通讯作者 | Ye, Mao(goldleaf@hnu.edu.cn) ; Xiong, Wei(weixiong420@csu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn) |
| 英文摘要 | Uveal melanoma (UM) is the most common primary intraocular malignancy among adults. Despite significant advances in diagnosis and treatment, the general mortality of UM remains alarmingly high. This calls for the development of new approaches for the treatment of UM, such as targeted cancer therapy. CD71, also known as transferrin receptor 1, is overexpressed in UM cell lines and tissues. Herein, we report the development of a CD71-specific aptamer targeting the XQ-2dMMAE conjugate that can distinguish UM cells from normal human uveal melanocytes. The cytotoxic drug monomethyl auristatin E (MMAE) could be easily coupled onto XQ-2d, a DNA aptamer that specifically targets CD71, to achieve efficiently targeted cancer growth inhibition in a mouse xenograft model, thus implying that XQ-2d-MMAE might be developed into a promising novel anti-tumor agent for the treatment of UM. Collectively, our results demonstrated that CD71 is a reliable target for drug delivery in UM and could be utilized as a model to explore aptamermediated targeted UM treatment strategies. |
| WOS关键词 | TRANSFERRIN RECEPTOR 1 ; TARGETED DELIVERY ; IRON-METABOLISM ; CANCER ; AGENTS ; TUMOR |
| 资助项目 | National Natural Science Foundation of China[21890744] ; National Natural Science Foundation of China[82071006] ; National Natural Science Foundation of China[81672760] ; Hunan Provincial Key Research and Development Plan[2018SK2128] ; China Postdoctoral Science Foundation[2020M681926] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000734455100001 |
| 资助机构 | National Natural Science Foundation of China ; Hunan Provincial Key Research and Development Plan ; China Postdoctoral Science Foundation |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/127143]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Ye, Mao; Xiong, Wei; Tan, Weihong |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China 2.Hunan Univ, Coll Biol, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hui,Jin, Cheng,Zhang, Lin,et al. CD71-Specific Aptamer Conjugated with Monomethyl Auristatin E for the Treatment of Uveal Melanoma[J]. ACS APPLIED MATERIALS & INTERFACES,2021. |
| APA | Zhang, Hui.,Jin, Cheng.,Zhang, Lin.,Peng, Bo.,Zhang, Yibin.,...&Tan, Weihong.(2021).CD71-Specific Aptamer Conjugated with Monomethyl Auristatin E for the Treatment of Uveal Melanoma.ACS APPLIED MATERIALS & INTERFACES. |
| MLA | Zhang, Hui,et al."CD71-Specific Aptamer Conjugated with Monomethyl Auristatin E for the Treatment of Uveal Melanoma".ACS APPLIED MATERIALS & INTERFACES (2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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