Genomic Analysis Reveals Heterogeneity Between Lesions in Synchronous Primary Right-Sided and Left-Sided Colon Cancer
文献类型：期刊论文
| 作者 | Hu, Hanqing3; Zhang, Qian2; Huang, Rui3; Gao, Zhifeng1; Yuan, Ziming3; Tang, Qingchao3; Gao, Feng3; Wang, Meng2; Zhang, Weiyuan3; Ma, Tianyi3 |
| 刊名 | FRONTIERS IN MOLECULAR BIOSCIENCES
 |
| 出版日期 | 2021-08-04 |
| 卷号 | 8 |
| 关键词 | synchronous multiple primary cancer genome right-sided colon cancer left-sided colon cancer heterogeneity |
| DOI | 10.3389/fmolb.2021.689466 |
| 通讯作者 | Wang, Guiyu(guiywang@163.com) |
| 英文摘要 | Background: The synchronous primary right-sided and left-sided colon cancer (sRL-CC) is a peculiar subtype of colorectal cancer. However, the genomic landscape of sRL-CC remains elusive. Methods: Twenty-eight paired tumor samples and their corresponding normal mucosa samples from 14 patients were collected from the Second Affiliated Hospital of Harbin Medical University from 2011 to 2018. The clinical-pathological data were obtained, and whole-exome sequencing was performed based on formalin-fixed and paraffin-embedded samples of these patients, and then, comprehensive bioinformatic analyses were conducted. Results: Both the lesions of sRL-CC presented dissimilar histological grade and differentiation. Based on sequencing data, few overlapping SNV signatures, oncodriver gene mutations, and SMGs were identified. Moreover, the paired lesions harbored a different distribution of copy number variants (CNVs) and loss of heterozygosity. The clonal architecture analysis demonstrated the polyclonal origin of sRL-CC and inter-cancerous heterogeneity between two lesions. Conclusion: Our work provides evidence that lesions of sRL-CC share few overlapping mutational signatures and CNVs, and may originate from different clones. |
| WOS关键词 | CONSENSUS MOLECULAR SUBTYPES ; MUTATIONAL PROCESSES ; MICROTUBULE ORGANIZATION ; SIGNATURES ; LANDSCAPE ; EVOLUTION ; DISTAL |
| 资助项目 | China Postdoctoral Science Foundation[2018M641856] ; Heilongjiang Postdoctoral Fund[LBHZ18200] ; Heilongjiang Applied and Development Program[GA19C003] ; Natural Science Foundation of Heilongjiang Province[H2017016] ; Postgraduate Research & Practice Innovation Program of Harbin Medical University[YJSKYCX 201951HYD] ; National Natural Science Foundation of China[81872034] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000685044700003 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | China Postdoctoral Science Foundation ; Heilongjiang Postdoctoral Fund ; Heilongjiang Applied and Development Program ; Natural Science Foundation of Heilongjiang Province ; Postgraduate Research & Practice Innovation Program of Harbin Medical University ; National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/127197]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Guiyu |
| 作者单位 | 1.Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Surg, Xian, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Colorectal Canc Surg Dept, Hangzhou, Peoples R China 3.Harbin Med Univ, Affiliated Hosp 2, Colorectal Canc Surg Dept, Harbin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Hanqing,Zhang, Qian,Huang, Rui,et al. Genomic Analysis Reveals Heterogeneity Between Lesions in Synchronous Primary Right-Sided and Left-Sided Colon Cancer[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2021,8. |
| APA | Hu, Hanqing.,Zhang, Qian.,Huang, Rui.,Gao, Zhifeng.,Yuan, Ziming.,...&Wang, Guiyu.(2021).Genomic Analysis Reveals Heterogeneity Between Lesions in Synchronous Primary Right-Sided and Left-Sided Colon Cancer.FRONTIERS IN MOLECULAR BIOSCIENCES,8. |
| MLA | Hu, Hanqing,et al."Genomic Analysis Reveals Heterogeneity Between Lesions in Synchronous Primary Right-Sided and Left-Sided Colon Cancer".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。