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Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review

文献类型：期刊论文

作者Chen, Yamei4; Jin, Ying3,4; Hu, Xiao2,4; Chen, Ming1,4
刊名JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
出版日期2022-01-08
关键词Small cell lung cancer Tumor-infiltrating lymphocyte T cell Tumor microenvironment
ISSN号0171-5216
DOI10.1007/s00432-021-03895-x
通讯作者Hu, Xiao(huxiao@zjcc.org.cn) ; Chen, Ming(chenming@zicc.org.cn)
英文摘要Immune checkpoint inhibitors (ICIs) have brought new hope for the treatment of patients with small cell lung cancer (SCLC) over the past decades. However, the overall response rate is limited, and is lower than that in non-small cell lung cancer (NSCLC). This is in part because of the lack of pre-existing tumor-infiltrating T lymphocytes (TITLs), especially cytotoxic T cells (CTLs), in the SCLC tumor microenvironment (TME), resulting in insufficient anti-tumor immune response. To unleash the full potential of ICIs, the trafficking and infiltration of TITLs to the tumor is necessary and tightly regulated, the highly immunosuppressive tumor microenvironment blunts the infiltration and function of TITLs that reach the tumor in SCLC. Here, we review the characteristics of TITLs, the effects of various factors on T cell infiltration, and possible strategies to restore or promote T cell infiltration in the TME of SCLC.
WOS关键词ENDOTHELIAL GROWTH-FACTOR ; DNA-DAMAGE RESPONSE ; PD-L1 EXPRESSION ; ANTITUMOR IMMUNITY ; EXTRACELLULAR-MATRIX ; MESSENGER-RNA ; PROGNOSIS ; IMMUNOTHERAPY ; INHIBITION ; RECEPTORS
资助项目National Natural Science Foundation of China[81672972] ; Medical and Health Science Foundation of Zhe Jiang Province[2018255396] ; Medical and Health Science Foundation of Zhe Jiang Province[2019PY002]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000740400500002
出版者SPRINGER
资助机构National Natural Science Foundation of China ; Medical and Health Science Foundation of Zhe Jiang Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/127239]  
专题中国科学院合肥物质科学研究院
通讯作者Hu, Xiao; Chen, Ming
作者单位1.Sun Yat Sen Univ, Dept Radiat Oncol, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
2.Univ Chinese Acad Sci, Dept Radiat Oncol, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
3.Univ Chinese Acad Sci, Dept Med Oncol, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
4.Univ Chinese Acad Sci, Zhejiang Key Lab Radiat Oncol, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Yamei,Jin, Ying,Hu, Xiao,et al. Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2022.
APA Chen, Yamei,Jin, Ying,Hu, Xiao,&Chen, Ming.(2022).Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY.
MLA Chen, Yamei,et al."Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022).

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来源：合肥物质科学研究院

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