Lactobacillus casei JY300-8 generated by (12)C6+beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice
文献类型:期刊论文
作者 | Xu, Fuqiang1,3; Li, Qiaoqiao1,3; Wang, Shuyang1,2,3; Bai, Jin1,3; Dong, Miaoyin1,3; Xiao, Guoqing1,3; Wang, Junkai4 |
刊名 | JOURNAL OF FUNCTIONAL FOODS |
出版日期 | 2021-12-01 |
卷号 | 87页码:14 |
ISSN号 | 1756-4646 |
关键词 | Probiotic Functional foods Lactobacillus casei Heavy ion beams induced-mutagenesis Microbiota Colon cancer |
DOI | 10.1016/j.jff.2021.104779 |
通讯作者 | Wang, Shuyang(wangsy@impcas.ac.cn) ; Xiao, Guoqing(xiaogq@impcas.ac.cn) |
英文摘要 | Probiotics, as novel functional foods via microbiota-modulation to enhance host health and inhibit tumor carcinogenesis, have been attracted considerable interests. L. casei JY, as a potential probiotic, was irradiated by 12C6+ beams and a new mutant strain JY300-8 was generated through three round selections of transit tolerance in the upper human gastrointestinal tract, adhesion ability to Caco-2 cells and inhibitory pathogenic microorganisms, respectively. Interestingly, JY300-8 presented excellent properties, including the strongest adhesion ability (86.81%) to Caco-2 cells to our knowledge and more excellent antimicrobial properties, which was used for the potential candidate probiotic. Additionally, JY300-8 could significantly inhibit the proliferation of Caco2, HT29 and HCT116 cells in vitro, respectively. Furthermore, there were better therapeutic effects at an early stage in colon cancer mice, which included the similar survival rates (90%) and stronger inhibitory effect on tumor (83.48%), lower treatment cost and less side effects in comparison to the therapy drug (DFUR) for colon cancer (65.65%), which was attributed to promoting the apoptosis of colon cells and enhancing antitumor response via modulation cancer-induced gut microbiota dysbiosis by oral administration of JY300-8. Therefore, JY300-8 has great potential for bio-prophylactic and bio-therapeutic functional food in colon carcinogenesis. This work provided a promising approach that could improve human health, reduce greatly cancer incidence and mitigate cancer progression via modulation gut microbiota by excellent probiotics intervention. |
WOS关键词 | LACTIC-ACID BACTERIA ; BILE-SALT HYDROLASE ; IN-VITRO ; COLON CARCINOGENESIS ; STRAINS ; PROBIOTICS ; CANCER ; RESISTANCE ; CELLS ; 5-FLUOROURACIL |
资助项目 | HONGGUANG Special Project of Chinese Academy of Sciences[Y700050YHG] ; National Natural Science Foundation of China[12075294] ; Local Cooperation Project of the Chinese Academy of Sciences[YD-2021-01] |
WOS研究方向 | Food Science & Technology ; Nutrition & Dietetics |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000707261400005 |
资助机构 | HONGGUANG Special Project of Chinese Academy of Sciences ; National Natural Science Foundation of China ; Local Cooperation Project of the Chinese Academy of Sciences |
源URL | [http://119.78.100.186/handle/113462/136228] |
专题 | 中国科学院近代物理研究所 |
通讯作者 | Wang, Shuyang; Xiao, Guoqing |
作者单位 | 1.Univ Chinese Acad Sci, Coll Nucl Sci & Technol, Beijing, Peoples R China 2.Gansu Acad Sci, Inst Biol, Lanzhou, Gansu, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Gansu, Peoples R China 4.Northwest Normal Univ, Coll Phys, Anning Rd, Lanzhou 730000, Gansu, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Fuqiang,Li, Qiaoqiao,Wang, Shuyang,et al. Lactobacillus casei JY300-8 generated by (12)C6+beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice[J]. JOURNAL OF FUNCTIONAL FOODS,2021,87:14. |
APA | Xu, Fuqiang.,Li, Qiaoqiao.,Wang, Shuyang.,Bai, Jin.,Dong, Miaoyin.,...&Wang, Junkai.(2021).Lactobacillus casei JY300-8 generated by (12)C6+beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice.JOURNAL OF FUNCTIONAL FOODS,87,14. |
MLA | Xu, Fuqiang,et al."Lactobacillus casei JY300-8 generated by (12)C6+beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice".JOURNAL OF FUNCTIONAL FOODS 87(2021):14. |
入库方式: OAI收割
来源:近代物理研究所
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