Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma
文献类型：期刊论文
| 作者 | Li, Hong-Bin1; Wang, Jian-Li2; Jin, Xiao-Dong3 ; Zhao, Lei4; Ye, Hui-Li4; Kuang, Yan-Bei3; Ma, Yong5; Jiang, Xiang-Yan5; Yu, Ze-Yuan5
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| 刊名 | BMC CANCER
 |
| 出版日期 | 2021-09-16 |
| 卷号 | 21期号:1页码:18 |
| 关键词 | S100A Pancreatic ductal adenocarcinoma Biomarkers Prognosis Bioinformatics |
| DOI | 10.1186/s12885-021-08769-6 |
| 通讯作者 | Yu, Ze-Yuan(yuzy17@lzu.edu.cn) |
| 英文摘要 | Background Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory malignancy with poor prognosis. It is urgent to identify novel and valid biomarkers to predict the progress and prognosis of PDAC. The S100A family have been identified as being involved in cell proliferation, migration and differentiation progression of various cancer types. However, the expression patterns and prognostic values of S100As in PDAC remain to be analyzed. Methods We investigated the transcriptional expressions, methylation level and prognostic value of S100As in PDAC patients from the Oncomine, GEPIA2, Linkedomics and cBioPortal databases. Real-time PCR was used to detect the expressions of S100A2/4/6/10/14/16 in four pancreatic cancer cell lines and pancreatic cancer tissues from PDAC patients undergoing surgery. To verify the results further, immunohistochemistry was used to measure the expression of S100A2/4/6/10/14/16 in 43 PDAC patients' tissue samples. The drug relations of S100As were analyzed by using the Drugbank database. Results The results suggested that, the expression levels of S100A2/4/6/10/14/16 were elevated to PDAC tissues than in normal pancreatic tissues, and the promoter methylation levels of S100A S100A2/4/6/10/14/16 in PDAC (n = 10) were lower compared with normal tissue (n = 184) (P < 0.05). In addition, their expressions were negatively correlated with PDAC patient survival. Conclusions Taken together, these results suggest that S100A2/4/6/10/14/16 might be served as prognostic biomarkers for survivals of PDAC patients. |
| WOS关键词 | CANCER ; BINDING ; PROGRESSION ; PROTEINS |
| 资助项目 | National Natural Science Foundation of China[82003216] ; Fundamental Research Funds for the Central Universities[lzujbky-2017-78] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000696540700007 |
| 出版者 | BMC |
| 资助机构 | National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://119.78.100.186/handle/113462/136515]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Yu, Ze-Yuan |
| 作者单位 | 1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China 2.Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Res, Lanzhou 730050, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730030, Peoples R China 4.Lanzhou Univ, Cui Ying Biomed Res Ctr, Hosp 2, Lanzhou 730030, Peoples R China 5.Lanzhou Univ, Hosp 2, Dept Gen Surg, Gansu Prov Canc Hosp, 82 Cui Ying Men, Lanzhou 730030, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hong-Bin,Wang, Jian-Li,Jin, Xiao-Dong,et al. Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma[J]. BMC CANCER,2021,21(1):18. |
| APA | Li, Hong-Bin.,Wang, Jian-Li.,Jin, Xiao-Dong.,Zhao, Lei.,Ye, Hui-Li.,...&Yu, Ze-Yuan.(2021).Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma.BMC CANCER,21(1),18. |
| MLA | Li, Hong-Bin,et al."Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma".BMC CANCER 21.1(2021):18. |
入库方式： OAI收割
来源：近代物理研究所
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