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Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury

文献类型：期刊论文

作者Li, Yangyang2; Zhang, Yiming2; Wei, Kongxi2; He, Jinpeng3,4; Ding, Nan3,4; Hua, Junrui3,4; Zhou, Ting2; Niu, Fan2; Zhou, Gucheng2; Shi, Tongfan2
刊名FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
出版日期2021-07-09
卷号11页码:13
关键词radiotherapy gut microbiota dysbiosis metabolites SCFAs radiation-induced intestinal injury
ISSN号2235-2988
DOI10.3389/fcimb.2021.577236
通讯作者Zhang, Liying(zhangliying201212@163.com) ; Liu, Yongqi(liuyongqi73@163.com)
英文摘要Gut microbiota is regarded as the second human genome and forgotten organ, which is symbiotic with the human host and cannot live and exist alone. The gut microbiota performs multiple physiological functions and plays a pivotal role in host health and intestinal homeostasis. However, the gut microbiota can always be affected by various factors and among them, it is radiotherapy that results in gut microbiota (12)dysbiosis and it is often embodied in a decrease in the abundance and diversity of gut microbiota, an increase in harmful bacteria and a decrease in beneficial bacteria, thereby affecting many disease states, especially intestine diseases. Furthermore, gut microbiota can produce a variety of metabolites, among which short-chain fatty acids (SCFAs) are one of the most abundant and important metabolites. More importantly, SCFAs can be identified as second messengers to promote signal transduction and affect the occurrence and development of diseases. Radiotherapy can lead to the alterations of SCFAs-producing bacteria and cause changes in SCFAs, which is associated with a variety of diseases such as radiation-induced intestinal injury. However, the specific mechanism of its occurrence is not yet clear. Therefore, this review intends to emphasize the alterations of gut microbiota after radiotherapy and highlight the alterations of SCFAs-producing bacteria and SCFAs to explore the mechanisms of radiation-induced intestinal injury from the perspective of gut microbiota and its metabolite SCFAs.
WOS关键词CHAIN FATTY-ACIDS ; INFLAMMATORY-BOWEL-DISEASE ; HISTONE DEACETYLASE ; SODIUM-BUTYRATE ; VALPROIC ACID ; DOUBLE-BLIND ; CANCER ; HEALTH ; PREVENTION ; PROBIOTICS
资助项目National Natural Science Foundation of China[81973595] ; National Natural Science Foundation of China[82004094] ; China Postdoctoral Science Foundation Project[2021M693794] ; Open Fund Project of Key Laboratory of Dunhuang Medicine and Translational Education Ministry[DHYX19-13]
WOS研究方向Immunology ; Microbiology
语种英语
WOS记录号WOS:000677391500001
出版者FRONTIERS MEDIA SA
资助机构National Natural Science Foundation of China ; China Postdoctoral Science Foundation Project ; Open Fund Project of Key Laboratory of Dunhuang Medicine and Translational Education Ministry
源URL[http://119.78.100.186/handle/113462/136768]  
专题中国科学院近代物理研究所
通讯作者Zhang, Liying; Liu, Yongqi
作者单位1.Gansu Inst Cardiovasc Dis, Lanzhou, Peoples R China
2.Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China
3.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China
4.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China
5.Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yangyang,Zhang, Yiming,Wei, Kongxi,et al. Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2021,11:13.
APA Li, Yangyang.,Zhang, Yiming.,Wei, Kongxi.,He, Jinpeng.,Ding, Nan.,...&Liu, Yongqi.(2021).Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,11,13.
MLA Li, Yangyang,et al."Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 11(2021):13.

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来源：近代物理研究所

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