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Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation

文献类型：期刊论文

作者Li, Feifei2; Li, Zihou4; Jin, Xiaodong2; Liu, Yan2; Li, Ping2; Shen, Zheyu3; Wu, Aiguo3; Zheng, Xiaogang2; Chen, Weiqiang2; Li, Qiang2
刊名NANOSCALE RESEARCH LETTERS
出版日期2019
卷号14期号:1页码:12
关键词Radiosensitizing effect Gadolinium oxide nanocrystals DNA damage Apoptosis Cytotoxic autophagy Carbon ion radiotherapy
ISSN号1931-7573
DOI10.1186/s11671-019-3152-2
其他题名Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation
通讯作者Chen, Weiqiang(chenwq7315@impcas.ac.cn) ; Li, Qiang(liqiang@impcas.ac.cn)
英文摘要Gadolinium-based nanomaterials can not only serve as contrast agents but also contribute to sensitization in the radiotherapy of cancers. Among radiotherapies, carbon ion irradiation is considered one of the superior approaches with unique physical and biological advantages. However, only a few metallic nanoparticles have been used to improve carbon ion irradiation. In this study, gadolinium oxide nanocrystals (GONs) were synthesized using a polyol method to decipher the radiosensitizing mechanisms in non-small cell lung cancer (NSCLC) cell lines irradiated by carbon ions. The sensitizer enhancement ratio at the 10% survival level was correlated with the concentration of Gd in NSCLC cells. GONs elicited an increase in hydroxyl radical production in a concentration-dependent manner, and the yield of reactive oxygen species increased obviously in irradiated cells, which led to DNA damage and cell cycle arrest. Apoptosis and cytostatic autophagy were also significantly induced by GONs under carbon ion irradiation. The GONs may serve as an effective theranostic material in carbon ion radiotherapy for NSCLC.Graphical
WOS关键词CAPPED GOLD NANOPARTICLES ; LUNG-CANCER CELLS ; RADIATION-THERAPY ; DNA-DAMAGE ; INDUCED APOPTOSIS ; PARTICLE THERAPY ; AUTOPHAGY ; RADIOTHERAPY ; ENHANCEMENT ; CYCLE
资助项目[National Key Research and Development Program] ; [National Key Technology Support Program of the Ministry of Science and Technology of China] ; [National Natural Science Foundation of China]
WOS研究方向Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000492592700001
出版者SPRINGEROPEN
资助机构National Key Research and Development Program ; National Key Technology Support Program of the Ministry of Science and Technology of China ; National Natural Science Foundation of China
源URL[http://119.78.100.186/handle/113462/136906]  
专题中国科学院近代物理研究所
作者单位1.Institute of Modern Physics, Chinese Academy of Sciences
2.Chinese Acad Sci, Key Lab Basic Res Heavy Ion Radiat Applicat Med, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China
3.Ningbo Institute of Material Technology & Engineering, Chinese Academy of Sciences
4.University of Chinese Academy of Sciences, CAS
推荐引用方式
GB/T 7714		 Li, Feifei,Li, Zihou,Jin, Xiaodong,et al. Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation[J]. NANOSCALE RESEARCH LETTERS,2019,14(1):12.
APA Li, Feifei.,Li, Zihou.,Jin, Xiaodong.,Liu, Yan.,Li, Ping.,...&Li, Qiang.(2019).Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation.NANOSCALE RESEARCH LETTERS,14(1),12.
MLA Li, Feifei,et al."Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation".NANOSCALE RESEARCH LETTERS 14.1(2019):12.

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来源：近代物理研究所

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