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LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation

文献类型：期刊论文

作者Kuang, Yanbei1,2,3,4; Bing, Zhitong1,2,3,4; Jin, Xiaodong1,2,3,4; Li, Qiang1,2,3,4
刊名BIOMED RESEARCH INTERNATIONAL
出版日期2021-06-01
卷号2021页码:10
ISSN号2314-6133
DOI10.1155/2021/1728352
通讯作者Jin, Xiaodong(jinxd@impcas.ac.cn) ; Li, Qiang(liqiang@impcas.ac.cn)
英文摘要Previous studies have indicated that radiation resistance of glioma is one of the leading causes of radiotherapy failure. Mounting evidence suggests that long non-coding RNA (lncRNA) plays an important role in regulating radiosensitivity of cancer cells via implicating in various cell processes. However, the underlying mechanisms remain unclear and need further study, especially at the molecular level. We found that the expression level of lncRNA H19 was elevated by radiation, and then, the modulation of H19 affected the resistant of glioma cells to X-rays. Dual-luciferase reporter analyses showed that H19 was transcriptionally activated by CREB1 in glioma cells after irradiation. In addition, both flow cytometry and 5-ethynyl-2'-deoxyuridine (EdU) assay suggested that H19 was involved in the cell cycle arrest, apoptosis, and DNA synthesis to modulate the radiation response of glioma cells and influenced their radioresistance. Therefore, H19 might play a crucial role in enhancing the radioresistance of glioma.
WOS关键词CENTRAL-NERVOUS-SYSTEM ; CREB ; PROLIFERATION ; TUMORS
资助项目National Key Research Program of China[2018YFC0115700] ; National Key Research Program of China[2018YFC0115702] ; National Natural Science Foundation of China[11875299] ; National Natural Science Foundation of China[U1532264] ; Key Deployment Project of Chinese Academy of Sciences[KFZD-SW-222] ; National Natural Science Foundation of Chinese Academy of Engineering Physics[U1730133]
WOS研究方向Biotechnology & Applied Microbiology ; Research & Experimental Medicine
语种英语
出版者HINDAWI LTD
WOS记录号WOS:000664104000006
资助机构National Key Research Program of China ; National Natural Science Foundation of China ; Key Deployment Project of Chinese Academy of Sciences ; National Natural Science Foundation of Chinese Academy of Engineering Physics
源URL[http://119.78.100.186/handle/113462/137032]  
专题中国科学院近代物理研究所
通讯作者Jin, Xiaodong; Li, Qiang
作者单位1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Kuang, Yanbei,Bing, Zhitong,Jin, Xiaodong,et al. LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation[J]. BIOMED RESEARCH INTERNATIONAL,2021,2021:10.
APA Kuang, Yanbei,Bing, Zhitong,Jin, Xiaodong,&Li, Qiang.(2021).LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation.BIOMED RESEARCH INTERNATIONAL,2021,10.
MLA Kuang, Yanbei,et al."LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation".BIOMED RESEARCH INTERNATIONAL 2021(2021):10.

入库方式： OAI收割

来源：近代物理研究所

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