Identification of novel biomarkers of heavy ion exposure: Proteins, miRNAs and tRNA-derived fragments in serum
文献类型：期刊论文
| 作者 | Bai, Hao1,2,3; Zhang, Tongshan1,2,3; Wang, Jufang1,2,3 ; Hua, Junrui1,2; Wei, Wenjun1,2
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| 刊名 | ACTA ASTRONAUTICA
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| 出版日期 | 2021-09-01 |
| 卷号 | 186页码:329-336 |
| ISSN号 | 0094-5765 |
| 关键词 | Heavy ions Serum Biomarkers Protein miRNA tRF&tiRNA |
| DOI | 10.1016/j.actaastro.2021.05.047 |
| 通讯作者 | Wei, Wenjun(weiwenjun@impcas.ac.cn) |
| 英文摘要 | Space radiation is a major concern for human spaceflight. Especially, the heavy ions in cosmic rays can result in more serious DNA damage and uncertain consequences in carcinogenesis comparing with conventional radiation such as X- or gamma-rays. Minimally invasive biomarkers that can be easily and quickly detected at an early stage are valuable for risk assessment of astronauts' space radiation exposure. Serum molecules originating from tissues and blood cells have been emerging as ideal biomarkers. However, the molecules that respond to low dose of heavy ion radiation have not been reported. Here, mice were total-body exposed to different doses of carbon ions with linear energy transfer (LET) of 30 keV/mu m. Mouse Antibody Array and RNA sequencing were performed to detect expression profiles of serum proteins and small non-coding RNAs (sncRNAs) at 24 h post-irradiation. After conditional screening and further validation, the expression of 2 proteins, 3 miRNAs and 2 tRNA-derived fragments showed obvious increase or decrease with increasing dose, even in the mice that received as low as 0.1 Gy or 0.5 Gy of carbon ion radiation. In this study, we identified some new proteins, miRNAs and tRNA-derived fragments in serum showing great potential as early biomarkers of exposure to energetic heavy ions. These results might be useful to dose reconstruction and risk assessment of heavy ion exposure in deep space exploration. |
| WOS关键词 | CHROMOSOME-ABERRATIONS ; BLOOD-LYMPHOCYTES ; RADIATION ; MICRORNAS ; BIOGENESIS ; BIODOSIMETRY ; ASTRONAUTS ; MECHANISM ; PROTEOME |
| 资助项目 | Innovation Center of Antiirradiation Application Technology of National Science and Technology Industry[KFZC2020010701] ; National Natural Science Foundation of China[11805246] ; CAS Light of West China program ; Science and Technology Research Project of Gansu Province[17JR5RA307] ; Science and Technology Research Project of Gansu Province[145RTSA012] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000670759300028 |
| 资助机构 | Innovation Center of Antiirradiation Application Technology of National Science and Technology Industry ; National Natural Science Foundation of China ; CAS Light of West China program ; Science and Technology Research Project of Gansu Province |
| 源URL | [http://119.78.100.186/handle/113462/137065]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Wei, Wenjun |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, CAS Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Hao,Zhang, Tongshan,Wang, Jufang,et al. Identification of novel biomarkers of heavy ion exposure: Proteins, miRNAs and tRNA-derived fragments in serum[J]. ACTA ASTRONAUTICA,2021,186:329-336. |
| APA | Bai, Hao,Zhang, Tongshan,Wang, Jufang,Hua, Junrui,&Wei, Wenjun.(2021).Identification of novel biomarkers of heavy ion exposure: Proteins, miRNAs and tRNA-derived fragments in serum.ACTA ASTRONAUTICA,186,329-336. |
| MLA | Bai, Hao,et al."Identification of novel biomarkers of heavy ion exposure: Proteins, miRNAs and tRNA-derived fragments in serum".ACTA ASTRONAUTICA 186(2021):329-336. |
入库方式： OAI收割
来源：近代物理研究所
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