The influence of beam delivery uncertainty on dose uniformity and penumbra for pencil beam scanning in carbon-ion radiotherapy
文献类型：期刊论文
| 作者 | Li, Yue2,3 ; Gao, Yunzhe1,2,3; Liu, Xinguo2; Shi, Jian2; Xia, Jiawen1,2,3; Yang, Jiancheng2; Mao, Lijun2
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| 刊名 | PLOS ONE
 |
| 出版日期 | 2021-04-01 |
| 卷号 | 16期号:4页码:18 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0249452 |
| 通讯作者 | Mao, Lijun(maolijun@impcas.ac.cn) |
| 英文摘要 | The dose uniformity and penumbra in the treatment field are important factors in radiotherapy, which affects the outcomes of radiotherapy. In this study, the integrated depth-dose-distributions (IDDDs) of 190 MeV/u and 260 MeV/u carbon beams in the active spot-scanning delivery system were measured and calculated by FLUKA Monte Carlo simulation based on the Heavy Ion Medical Machine (HIMM). Considering the dose distributions caused by secondary particles and scattering, we also used different types of pencil beam (PB) models to fit and compare the spatial distributions of PB. We superposed a bunch of PB to form a 20x20 cm(2) treatment field with the double Gaussian and double Gaussian logistic beam models and calculated the influence of beam delivery error on the field flatness and penumbra, respectively. The simulated IDDDs showed good agreement with the measured values. The triple Gaussian and double Gaussian logistic beam models have good fitness to the simulated dose distributions. There are different influences on dose uniformity and penumbra resulting from beam uncertainties. These results would be helpful for understanding carbon ion therapy, and physical therapists are more familiar with beam characteristics for active scanning therapy, which provides a reference for commissioning and optimization of treatment plans in radiotherapy. |
| 资助项目 | Guangdong Innovative and Entrepreneurial Research Team Program[2016ZT06G373] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000636467000077 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 资助机构 | Guangdong Innovative and Entrepreneurial Research Team Program |
| 源URL | [http://119.78.100.186/handle/113462/137650]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Mao, Lijun |
| 作者单位 | 1.Huizhou Res Ctr Ion Sci, Huizhou, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yue,Gao, Yunzhe,Liu, Xinguo,et al. The influence of beam delivery uncertainty on dose uniformity and penumbra for pencil beam scanning in carbon-ion radiotherapy[J]. PLOS ONE,2021,16(4):18. |
| APA | Li, Yue.,Gao, Yunzhe.,Liu, Xinguo.,Shi, Jian.,Xia, Jiawen.,...&Mao, Lijun.(2021).The influence of beam delivery uncertainty on dose uniformity and penumbra for pencil beam scanning in carbon-ion radiotherapy.PLOS ONE,16(4),18. |
| MLA | Li, Yue,et al."The influence of beam delivery uncertainty on dose uniformity and penumbra for pencil beam scanning in carbon-ion radiotherapy".PLOS ONE 16.4(2021):18. |
入库方式： OAI收割
来源：近代物理研究所
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