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The crosstalk between HIFs and mitochondrial dysfunctions in cancer development

文献类型：期刊论文

作者Bao, Xingting1,2,3,4,5; Zhang, Jinhua1,2,3,4,5; Huang, Guomin1,2,3,4,5; Yan, Junfang1,2,3,4,5; Xu, Caipeng1,2,3,4,5; Dou, Zhihui1,2,3,4,5; Sun, Chao1,2,3,4,5; Zhang, Hong1,2,3,4,5
刊名CELL DEATH & DISEASE
出版日期2021-02-26
卷号12期号:2页码:13
ISSN号2041-4889
DOI10.1038/s41419-021-03505-1
通讯作者Sun, Chao(sunchao@impcas.ac.cn) ; Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要Mitochondria are essential cellular organelles that are involved in regulating cellular energy, metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic disease that is closely associated with mitochondrial dysfunction. Hypoxia-inducible factors (HIFs), which are major molecules that respond to hypoxia, play important roles in cancer development by participating in multiple processes, such as metabolism, proliferation, and angiogenesis. The Warburg phenomenon reflects a pseudo-hypoxic state that activates HIF-1 alpha. In addition, a product of the Warburg effect, lactate, also induces HIF-1 alpha. However, Warburg proposed that aerobic glycolysis occurs due to a defect in mitochondria. Moreover, both HIFs and mitochondrial dysfunction can lead to complex reprogramming of energy metabolism, including reduced mitochondrial oxidative metabolism, increased glucose uptake, and enhanced anaerobic glycolysis. Thus, there may be a connection between HIFs and mitochondrial dysfunction. In this review, we systematically discuss the crosstalk between HIFs and mitochondrial dysfunctions in cancer development. Above all, the stability and activity of HIFs are closely influenced by mitochondrial dysfunction related to tricarboxylic acid cycle, electron transport chain components, mitochondrial respiration, and mitochondrial-related proteins. Furthermore, activation of HIFs can lead to mitochondrial dysfunction by affecting multiple mitochondrial functions, including mitochondrial oxidative capacity, biogenesis, apoptosis, fission, and autophagy. In general, the regulation of tumorigenesis and development by HIFs and mitochondrial dysfunction are part of an extensive and cooperative network.
资助项目Institute of Modern Physics, Chinese Academy of Sciences ; Advanced Energy Science, Technology Guangdong Laboratory ; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences ; College of Life Sciences, University of Chinese Academy of Sciences ; School of Nuclear Science and Technology, University of Chinese Academy of Sciences ; National Key R&D Program of China[2018YFE0205100] ; Key Program of the National Natural Science Foundation of China[U1632270] ; National Natural Science Foundation of China[11775280] ; CAS Light of West China Program[Y866020XB0] ; Fellow of Youth Innovation Promotion Association[2020414]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000624654300004
出版者SPRINGERNATURE
资助机构Institute of Modern Physics, Chinese Academy of Sciences ; Advanced Energy Science, Technology Guangdong Laboratory ; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences ; College of Life Sciences, University of Chinese Academy of Sciences ; School of Nuclear Science and Technology, University of Chinese Academy of Sciences ; National Key R&D Program of China ; Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS Light of West China Program ; Fellow of Youth Innovation Promotion Association
源URL[http://119.78.100.186/handle/113462/137718]  
专题中国科学院近代物理研究所
通讯作者Sun, Chao; Zhang, Hong
作者单位1.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China
3.Adv Energy Sci & Technol Guangdong Lab, Guangzhou, Guangdong, Peoples R China
4.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou, Peoples R China
5.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 101408, Peoples R China
推荐引用方式
GB/T 7714		 Bao, Xingting,Zhang, Jinhua,Huang, Guomin,et al. The crosstalk between HIFs and mitochondrial dysfunctions in cancer development[J]. CELL DEATH & DISEASE,2021,12(2):13.
APA Bao, Xingting.,Zhang, Jinhua.,Huang, Guomin.,Yan, Junfang.,Xu, Caipeng.,...&Zhang, Hong.(2021).The crosstalk between HIFs and mitochondrial dysfunctions in cancer development.CELL DEATH & DISEASE,12(2),13.
MLA Bao, Xingting,et al."The crosstalk between HIFs and mitochondrial dysfunctions in cancer development".CELL DEATH & DISEASE 12.2(2021):13.

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来源：近代物理研究所

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