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Carbon ion irradiation-induced DNA damage evokes cell cycle arrest and apoptosis via the pRb/E2F1/c-Myc signaling pathway in p53-deficient prostate cancer PC-3 cells

文献类型：期刊论文

作者Wang, Fang2,3; Xiao, Yi1; Yan, Jun-Fang3,5; Huang, Guo-Min3,5; Zhang, Jin-Hua3,5; Di, Cui-Xia3; Si, Jing3; Zhang, Hong3; Mao, Ai-Hong4
刊名NUCLEAR SCIENCE AND TECHNIQUES
出版日期2021-03-01
卷号32期号:3页码:12
关键词Carbon ion irradiation DNA damage Cell cycle arrest Apoptosis C-Myc Prostate cancer
ISSN号1001-8042
DOI10.1007/s41365-021-00861-7
通讯作者Zhang, Hong(zhangh@impcas.ac.cn) ; Mao, Ai-Hong(maoaih@aliyun.com)
英文摘要Carbon ion radiotherapy has the advantages of better therapeutic effect and fewer side effects compared with those of X-rays in many kinds of tumors, including prostate cancer, and thus is an attractive treatment approach for prostate cancer. However, the biological effects and underlying mechanisms of carbon ion irradiation in prostate cancer are not yet fully understood. Therefore, this study systematically compared the effects of carbon ion irradiation with those of X-ray irradiation on DNA damage response and found that carbon ion irradiation was more effective than X-ray irradiation. Carbon ion irradiation can induce a high level of DNA double-strand break damage, reflected by the number of gamma-H2A histone family member X foci, as well as by the foci lasting time and size. Moreover, carbon ion irradiation exhibited strong and long-lasting inhibitory effect on cell survival capability, induced prolonged cell cycle arrest, and increased apoptosis in PC-3 cells. As an underlying mechanism, we speculated that carbon ion irradiation-induced DNA damage evokes cell cycle arrest and apoptosis via the pRb/E2F1/c-Myc signaling pathway to enhance the radiosensitivity of p53-deficient prostate cancer PC-3 cells. Collectively, the present study suggests that carbon ion irradiation is more efficient than X-ray irradiation and may help to understand the effects of different radiation qualities on the survival potential of p53-deficient prostate cancer cells.
资助项目National Key R&D Program of China[2018YFE0205100] ; Key Program of the National Natural Science Foundation of China[U1632270] ; National Natural Science Foundation of China[11665003] ; Cancer Research Youth Science Foundation of Chinese Anti-cancer Association[CAYC18A06]
WOS研究方向Nuclear Science & Technology ; Physics
语种英语
WOS记录号WOS:000630343000003
出版者SPRINGER SINGAPORE PTE LTD
资助机构National Key R&D Program of China ; Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; Cancer Research Youth Science Foundation of Chinese Anti-cancer Association
源URL[http://119.78.100.186/handle/113462/137721]  
专题中国科学院近代物理研究所
通讯作者Zhang, Hong; Mao, Ai-Hong
作者单位1.Lanzhou Univ, Hosp 1, Dept Mammary Gland, Lanzhou 730000, Peoples R China
2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China
3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
4.Gansu Prov Acad Inst Med Res, Lanzhou 730050, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Fang,Xiao, Yi,Yan, Jun-Fang,et al. Carbon ion irradiation-induced DNA damage evokes cell cycle arrest and apoptosis via the pRb/E2F1/c-Myc signaling pathway in p53-deficient prostate cancer PC-3 cells[J]. NUCLEAR SCIENCE AND TECHNIQUES,2021,32(3):12.
APA Wang, Fang.,Xiao, Yi.,Yan, Jun-Fang.,Huang, Guo-Min.,Zhang, Jin-Hua.,...&Mao, Ai-Hong.(2021).Carbon ion irradiation-induced DNA damage evokes cell cycle arrest and apoptosis via the pRb/E2F1/c-Myc signaling pathway in p53-deficient prostate cancer PC-3 cells.NUCLEAR SCIENCE AND TECHNIQUES,32(3),12.
MLA Wang, Fang,et al."Carbon ion irradiation-induced DNA damage evokes cell cycle arrest and apoptosis via the pRb/E2F1/c-Myc signaling pathway in p53-deficient prostate cancer PC-3 cells".NUCLEAR SCIENCE AND TECHNIQUES 32.3(2021):12.

入库方式： OAI收割

来源：近代物理研究所

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