Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system
文献类型：期刊论文
| 作者 | Zhao, Baoquan2; Li, Xiaoman1,2,3; Li, Xingzhou2; Quan, Dongqin2; Zhang, Fang2; Hu, Burong3
|
| 刊名 | PLOS ONE
 |
| 出版日期 | 2021-01-29 |
| 卷号 | 16期号:1页码:15 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0238209 |
| 通讯作者 | Zhao, Baoquan(baoquanzhao@126.com) |
| 英文摘要 | Ilomastat, a broad-spectrum inhibitor of matrix metalloproteinases (MMPs), has drawn attentions for its function in alleviating radiation damage. However, the detailed mechanisms of Ilomastat's protection from animal model remain not fully clear. In this study, the C57BL/6 mice were pre-administrated with Ilomastat or vihicle for 2 h, and then total body of mice were exposed to 6 Gy of gamma-rays. The protective effect of Ilomastat on the hematopoietic system in the irradiated mice were investigated. We found that pretreatment with Ilomastat significantly reduced the level of TGF-beta 1 and TNF-alpha, and elevated the number of bone marrow (BM) mononuclear cells in the irradiated mice. Ilomastat pretreatment also increased the fraction of BM hematopoietic progenitor cells (HPCs) and hematopoietic stem cells (HSCs) at day 30 after irradiation, and protected the spleen of mouse from irradiation. These results suggest that Ilomastat promotes the recovery of hematopoietic injury in the irradiated mice, and thus contributes to the survival of mouse after irradiation. |
| WOS关键词 | NECROSIS-FACTOR-ALPHA ; BONE-MARROW ; MATRIX METALLOPROTEINASES ; RADIATION ; STEM ; INJURY ; MICE ; APOPTOSIS ; CELLS |
| 资助项目 | Military Medical Scientific and Technological Project[AWS17J009] ; Military Medical Scientific and Technological Project[BWS16J007] ; Military Medical Scientific and Technological Project[2018ZX09J18102] ; National Natural Science Foundation of China[11635013] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000613891400029 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 资助机构 | Military Medical Scientific and Technological Project ; National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/137754]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhao, Baoquan |
| 作者单位 | 1.Peking Univ, Sch Basic Med Sci, Inst Syst Biomed, Dept Radiat Med,Hlth Sci Ctr, Beijing, Peoples R China 2.Acad Mil Med Sci, Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Baoquan,Li, Xiaoman,Li, Xingzhou,et al. Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system[J]. PLOS ONE,2021,16(1):15. |
| APA | Zhao, Baoquan,Li, Xiaoman,Li, Xingzhou,Quan, Dongqin,Zhang, Fang,&Hu, Burong.(2021).Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system.PLOS ONE,16(1),15. |
| MLA | Zhao, Baoquan,et al."Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system".PLOS ONE 16.1(2021):15. |
入库方式： OAI收割
来源：近代物理研究所
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