MDMX phosphorylation-dependent p53 down regulation contributes to an immunosuppressive tumor microenvironment
文献类型：期刊论文
| 作者 | Wang Bing1 ; Lim Chuanbian2; Yan Jiawei2; Li Lizhen2; Wang Jufang1; Little John B2; Yuan Zhimin2
|
| 刊名 | Journal of Molecular Cell Biology
 |
| 出版日期 | 2020 |
| 卷号 | 12期号:9页码:713-722 |
| 关键词 | p53 MDMX tumor microenvironment immune cell infiltration macrophage polarization |
| ISSN号 | 1674-2788 |
| 英文摘要 | A role of tumor-suppressive activity of p53 in the tumor microenvironment (TME) has been implicated but remains fairly understudied.To address this knowledge gap, we leveraged our Mdmx~(S314A) mice as recipients to investigate how implanted tumor cells incapacitate host p53 creating a conducive TME for tumor progression.We found that tumor cell-associated stress induced p53 downregulation in peritumor cells via an MDMX-Ser314 phosphorylation-dependent manner.As a result, an immunosuppressive TME was developed, as reflected by diminished immune cell infiltration into tumors and compromised macrophage M1 polarization.Remarkably, ablation of MDMX-Ser314 phosphorylation attenuated p53 decline in peritumor cells, which was associated with mitigation of immunosuppression and significant tumor growth delay.Our data collectively uncover a novel role of p53 in regulating the tumor immune microenvironment, suggesting that p53 restoration in the TME can be exploited as a potential strategy of anticancer therapy. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6879570 |
| 源URL | [http://119.78.100.186/handle/113462/137997]  |
| 专题 | 中国科学院近代物理研究所 |
| 作者单位 | 1.中国科学院近代物理研究所 2.John B.Little Center for Radiation Sciences, Harvard T.H.Chan School of Public Health |
| 推荐引用方式 GB/T 7714 | Wang Bing,Lim Chuanbian,Yan Jiawei,et al. MDMX phosphorylation-dependent p53 down regulation contributes to an immunosuppressive tumor microenvironment[J]. Journal of Molecular Cell Biology,2020,12(9):713-722. |
| APA | Wang Bing.,Lim Chuanbian.,Yan Jiawei.,Li Lizhen.,Wang Jufang.,...&Yuan Zhimin.(2020).MDMX phosphorylation-dependent p53 down regulation contributes to an immunosuppressive tumor microenvironment.Journal of Molecular Cell Biology,12(9),713-722. |
| MLA | Wang Bing,et al."MDMX phosphorylation-dependent p53 down regulation contributes to an immunosuppressive tumor microenvironment".Journal of Molecular Cell Biology 12.9(2020):713-722. |
入库方式： OAI收割
来源：近代物理研究所
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