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Carbon Ion Irradiation Enhances the Anti-tumor Efficiency in Tongue Squamous Cell Carcinoma via Modulating the FAK Signaling

文献类型：期刊论文

作者Si, Qingzong2; Ye, Qian2; Bing, Zhitong3; Fan, Ruihong2; Hu, Xiaoli3; Liu, Bin2; Wang, Jizeng1; Liu, Yang3; An, Xiaoli2
刊名FRONTIERS IN PUBLIC HEALTH
出版日期2021-02-03
卷号9页码:9
关键词carbon ion irradiation FAK metastatic potential tongue squamous cell carcinoma cell growth
DOI10.3389/fpubh.2021.631118
通讯作者Liu, Yang(liuy@impcas.ac.cn) ; An, Xiaoli(anxl@lzu.edu.cn)
英文摘要Oral cancer is a very aggressive disease with high rates of recurrence and metastasis. This study aimed at addressing how efficiently tongue cancer is suppressed after carbon ion irradiation. Here, the close relationship between upregulated expression of focal adhesion kinase (FAK) and high metastatic status in tongue squamous cell carcinoma patients was validated using bioinformatics and immunohistochemical analyses. Our data indicated that FAK suppression significantly enhanced the killing effect induced by irradiation in the tongue cancer cell line CAL27, as evidenced by increased apoptotic induction and reduced colony formation. More importantly, in FAK-deficient cells, carbon ion irradiation was shown to remarkably inhibit migration and invasion by delaying wound healing and slowing down motility. Further studies revealed that irradiation exposure caused disorganization of the actin cytoskeleton and reduced cell adhesive energy in FAK-deficient cells. Moreover, carbon ion treatment, in combination with FAK silencing, markedly blocked the phosphorylation levels of FAK, and paxillin, which partly contributed to the reduced motility of tongue squamous cell carcinoma CAL27 cells. Collectively, these results suggest that the prominent obstructing role of carbon ion irradiation in the growth inhibition and metastatic behavior of tumors, including attenuation of cell adhesiveness, motility, and invasiveness, could be distinctly modulated by FAK-mediated downstream pathways.
资助项目Talent Innovation and Entrepreneurship Project of Lanzhou City[2018-RC-36] ; Clinical Research Center of Shanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University[2019YHJB10] ; Natural Science Foundation of Gansu Province[20JR5RA264]
WOS研究方向Public, Environmental & Occupational Health
语种英语
WOS记录号WOS:000618642700001
出版者FRONTIERS MEDIA SA
资助机构Talent Innovation and Entrepreneurship Project of Lanzhou City ; Clinical Research Center of Shanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University ; Natural Science Foundation of Gansu Province
源URL[http://119.78.100.186/handle/113462/138032]  
专题中国科学院近代物理研究所
通讯作者Liu, Yang; An, Xiaoli
作者单位1.Lanzhou Univ, Sch Civil Engn & Mech, Inst Solid Mech, Lanzhou, Peoples R China
2.Lanzhou Univ, Sch Stomatol, Lanzhou, Peoples R China
3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China
推荐引用方式
GB/T 7714		 Si, Qingzong,Ye, Qian,Bing, Zhitong,et al. Carbon Ion Irradiation Enhances the Anti-tumor Efficiency in Tongue Squamous Cell Carcinoma via Modulating the FAK Signaling[J]. FRONTIERS IN PUBLIC HEALTH,2021,9:9.
APA Si, Qingzong.,Ye, Qian.,Bing, Zhitong.,Fan, Ruihong.,Hu, Xiaoli.,...&An, Xiaoli.(2021).Carbon Ion Irradiation Enhances the Anti-tumor Efficiency in Tongue Squamous Cell Carcinoma via Modulating the FAK Signaling.FRONTIERS IN PUBLIC HEALTH,9,9.
MLA Si, Qingzong,et al."Carbon Ion Irradiation Enhances the Anti-tumor Efficiency in Tongue Squamous Cell Carcinoma via Modulating the FAK Signaling".FRONTIERS IN PUBLIC HEALTH 9(2021):9.

入库方式： OAI收割

来源：近代物理研究所

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