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Multiple functions of p21 in cancer radiotherapy

文献类型：期刊论文

作者Kuang, Yanbei4,5,6,7; Kang, Jian3; Li, Hongbin2; Liu, Bingtao4,5,6,7; Zhao, Xueshan1; Li, Linying4,5,6,7; Jin, Xiaodong4,5,6,7; Li, Qiang4,5,6,7
刊名JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
出版日期2021-02-05
页码20
关键词p21 Cell cycle Apoptosis DNA damage repair Cancer radiotherapy
ISSN号0171-5216
DOI10.1007/s00432-021-03529-2
通讯作者Jin, Xiaodong(jinxd@impcas.ac.cn) ; Li, Qiang(liqiang@impcas.ac.cn)
英文摘要Background Greater than half of cancer patients experience radiation therapy, for both radical and palliative objectives. It is well known that researches on radiation response mechanisms are conducive to improve the efficacy of cancer radiotherapy. p21 was initially identified as a widespread inhibitor of cyclin-dependent kinases, transcriptionally modulated by p53 and a marker of cellular senescence. It was once considered that p21 acts as a tumour suppressor mainly to restrain cell cycle progression, thereby resulting in growth suppression. With the deepening researches on p21, p21 has been found to regulate radiation responses via participating in multiple cellular processes, including cell cycle arrest, apoptosis, DNA repair, senescence and autophagy. Hence, a comprehensive summary of the p21's functions in radiation response will provide a new perspective for radiotherapy against cancer. Methods We summarize the recent pertinent literature from various electronic databases, including PubMed and analyzed several datasets from Gene Expression Omnibus database. This review discusses how p21 influences the effect of cancer radiotherapy via involving in multiple signaling pathways and expounds the feasibility, barrier and risks of using p21 as a biomarker as well as a therapeutic target of radiotherapy. Conclusion p21's complicated and important functions in cancer radiotherapy make it a promising therapeutic target. Besides, more thorough insights of p21 are needed to make it a safe therapeutic target.
资助项目National Key Research Program of China[2018YFC0115700] ; National Key Research Program of China[2018YFC0115702] ; National Natural Science Foundation of China[11875299] ; National Natural Science Foundation of China[U1532264] ; Key Deployment Project of Chinese Academy of Sciences[KFZD-SW-222] ; National Natural Science Foundation of Chinese Academy of Engineering Physics[U1730133]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000615118600001
出版者SPRINGER
资助机构National Key Research Program of China ; National Natural Science Foundation of China ; Key Deployment Project of Chinese Academy of Sciences ; National Natural Science Foundation of Chinese Academy of Engineering Physics
源URL[http://119.78.100.186/handle/113462/138062]  
专题中国科学院近代物理研究所
通讯作者Jin, Xiaodong; Li, Qiang
作者单位1.Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China
2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China
3.Lanzhou Univ Technol, Coll Energy & Power Engn, Lanzhou 730050, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China
6.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
7.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Kuang, Yanbei,Kang, Jian,Li, Hongbin,et al. Multiple functions of p21 in cancer radiotherapy[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2021:20.
APA Kuang, Yanbei.,Kang, Jian.,Li, Hongbin.,Liu, Bingtao.,Zhao, Xueshan.,...&Li, Qiang.(2021).Multiple functions of p21 in cancer radiotherapy.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,20.
MLA Kuang, Yanbei,et al."Multiple functions of p21 in cancer radiotherapy".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021):20.

入库方式： OAI收割

来源：近代物理研究所

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