LsrB, the hub of ABC transporters involved in the membrane damage mechanisms of heavy ion irradiation in Escherichia coli
文献类型：期刊论文
| 作者 | Li, Xin1,2,5 ; Chen, Lei1; Zhou, Haitao3; Gu, Shaobin1; Wu, Ying1; Wang, Bing1; Zhang, Miaomiao4,7; Ding, Nan4,7; Sun, Jiaju1; Pang, Xinyue6
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| 刊名 | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
 |
| 出版日期 | 2021-10-28 |
| 页码 | 10 |
| ISSN号 | 0955-3002 |
| 关键词 | ABC transporter biofilm heavy ion protein-protein interaction (PPI) network quorum sensing (QS) transcriptomic |
| DOI | 10.1080/09553002.2021.1987565 |
| 通讯作者 | Pang, Xinyue(pangxy78@haust.edu.cn) ; Lu, Dong(ld@impcas.ac.cn) |
| 英文摘要 | Background Ionizing radiation, especially heavy ion (HI) beams, has been widely used in biology and medicine. However, the mechanism of membrane damage by such radiation remains primarily uncharacterized. Purpose Transcriptomic profiles of Escherichia coli (E. coli) treated with HI illustrated the response mechanisms of the membrane, mainly ABC transporters, related genes regulated by antibiotics treatment through enrichment analyses of GO and KEGG. The networks of protein-protein interactions indicated that LsrB was the crucial one among the ABC transporters specially regulated by HI through the calculation of plugins MCODE and cytoHubba of Cytoscape. Finally, the expression pattern, GO/KEGG enrichment terms, and the interaction between nine LuxS/AI-2 quorum sensing system members were investigated. Conclusions Above all, results suggested that HI might perform membrane damage through regulated material transport, inhibited LuxS/AI-2 system, finally impeded biofilm formation. This work provides further evidence for the role of ABC transporters, especially LsrB, in membrane damage of E. coli to HI. It will provide new strategies for improving the precise application of HI. |
| WOS关键词 | BEAM IRRADIATION ; CARBON ; CELLS |
| 资助项目 | National Natural Science Foundation of China[11975284] ; National Natural Science Foundation of China[11905265] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| WOS记录号 | WOS:000713921800001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/138298]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Pang, Xinyue; Lu, Dong |
| 作者单位 | 1.Henan Univ Sci & Technol, Coll Food & Bioengn, Luoyang, Peoples R China 2.Natl Demonstrat Ctr Expt Food Proc & Safety Educ, Luoyang, Peoples R China 3.Zhengzhou Univ, Neurol Dept, Luoyang Cent Hosp, Luoyang, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 5.Key Lab Microbial Resources Exploitat & Utilizat, Luoyang, Peoples R China 6.Henan Univ Sci & Technol, Coll Med Technol & Engn, Luoyang, Peoples R China 7.Chinese Acad Sci, Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xin,Chen, Lei,Zhou, Haitao,et al. LsrB, the hub of ABC transporters involved in the membrane damage mechanisms of heavy ion irradiation in Escherichia coli[J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY,2021:10. |
| APA | Li, Xin.,Chen, Lei.,Zhou, Haitao.,Gu, Shaobin.,Wu, Ying.,...&Lu, Dong.(2021).LsrB, the hub of ABC transporters involved in the membrane damage mechanisms of heavy ion irradiation in Escherichia coli.INTERNATIONAL JOURNAL OF RADIATION BIOLOGY,10. |
| MLA | Li, Xin,et al."LsrB, the hub of ABC transporters involved in the membrane damage mechanisms of heavy ion irradiation in Escherichia coli".INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021):10. |
入库方式： OAI收割
来源：近代物理研究所
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