Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe
文献类型：期刊论文
| 作者 | Zhao, Jintao4; Qu, Yuan1; Gao, Hao1; Zhong, Miao4; Li, Xinming3,4; Zhang, Fang4; Chen, Yaxiong2,4 ; Gan, Lu2; Hu, Guodong4; Zhang, Hong2
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| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2020-11-21 |
| 卷号 | 56期号:90页码:14075-14078 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/d0cc05900e |
| 通讯作者 | Zhang, Shengxiang(sxzhang@lzu.edu.cn) ; Fang, Jianguo(fangjg@lzu.edu.cn) |
| 英文摘要 | Thioredoxin reductase (TrxR) enzymes are critical in regulating redox homeostasis in cells. We report the first two-photon fluorescent probe of mammalian TrxR (TP-TRFS). TP-TRFS retains high specificity in recognizing TrxR. More importantly, the two-photon absorbing character of TP-TRFS enables it to be used in vivo. With the aid of TP-TRFS, a remarkable decline of the TrxR function was observed in the brain of a mouse model of stroke for the first time, providing a mechanistic link of TrxR dysfunction with stroke. |
| WOS关键词 | CEREBRAL-ISCHEMIA ; OXIDATIVE STRESS ; INHIBITOR ; INJURY |
| 资助项目 | National Natural Science Foundation of China[21778028] ; National Natural Science Foundation of China[22077055] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000588834100031 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/138420]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Shengxiang; Fang, Jianguo |
| 作者单位 | 1.Lanzhou Univ, Sch Life Sci, Gansu Key Lab Biomonitoring & Bioremediat Environ, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, 509 Nanchang Rd, Lanzhou 730000, Peoples R China 3.East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China 4.Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Jintao,Qu, Yuan,Gao, Hao,et al. Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe[J]. CHEMICAL COMMUNICATIONS,2020,56(90):14075-14078. |
| APA | Zhao, Jintao.,Qu, Yuan.,Gao, Hao.,Zhong, Miao.,Li, Xinming.,...&Fang, Jianguo.(2020).Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe.CHEMICAL COMMUNICATIONS,56(90),14075-14078. |
| MLA | Zhao, Jintao,et al."Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe".CHEMICAL COMMUNICATIONS 56.90(2020):14075-14078. |
入库方式： OAI收割
来源：近代物理研究所
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