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Novel Carborane Compounds Based on Cyclooxygenase-2 Inhibitors for Effective Boron Neutron Capture Therapy of Tongue Squamous Cell Carcinoma

文献类型：期刊论文

作者Zhang, Taofeng1,3,4; Du, Shaobo1,3; Wang, Yu5; Guo, Yanzhu3; Yi, Yangman3; Liu, Bin1,3; Liu, Yang2; Chen, Ximeng1; Zhao, Quanyi6; He, Dian6
刊名CHEMISTRYSELECT
出版日期2020-12-11
卷号5期号:46页码:14652-14660
ISSN号2365-6549
关键词Boron neutron capture therapy Tongue squamous cell carcinoma COX-2 inhibitors Biological activity Growth factors
DOI10.1002/slct.202004077
通讯作者Liu, Bin(liubkq@lzu.edu.cn) ; Liu, Yang(liuy@impcas.ac.cn) ; Chen, Ximeng(chenxm@lzu.edu.cn)
英文摘要To date, the mortality of tongue squamous cell carcinoma (TSCC) is still high, COX-2 is highly expressed in the head and neck cancers, and targeting COX-2 is a potential treatment for TSCC. Herein, a series of novel carborane compounds based on COX-2 inhibitors have been developed for the effective treatment of TSCC by boron neutron capture therapy (BNCT). Notably, the compound 1 had high COX-2 selectivity and low cytotoxicity against CAL27 cells. Meanwhile, the compound 1 had higher selectivity and uptake of CAL27 cells compared to the positive control group sodium borocaptate (BSH). The apoptosis of CAL27 cells treated with the compound 1 during BNCT was significantly induced by breaking DNA double strands and generating excess reactive oxygen species, and the proliferation of cancer cells was inhibited by down-regulating the expression of cytokines associated with phosphatidylinositide 3-kinases/protein kinase B (PI3K/Akt) and mitogen-activated protein kinases (MAPKs) signaling pathways in BNCT. Thus, the carborane compounds based on COX-2 inhibitors have the potential to effectively treat tongue squamous cell carcinoma through BNCT.
WOS关键词OXIDATIVE STRESS ; UP-REGULATION ; EXPRESSION ; CANCER ; HEAD ; OVEREXPRESSION ; INFLAMMATION ; ENHANCEMENT ; RADIATION ; MICRORNA
资助项目National Natural Science Foundation of China[81970976] ; National Natural Science Foundation of China[11575262] ; Scientific Technology Research Projects of Gansu Province[18JR3RA377] ; Projects of Heavy Ion Research Facility in Lanzhou[HIR20PY012]
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000598232400019
资助机构National Natural Science Foundation of China ; Scientific Technology Research Projects of Gansu Province ; Projects of Heavy Ion Research Facility in Lanzhou
源URL[http://119.78.100.186/handle/113462/138435]  
专题中国科学院近代物理研究所
通讯作者Liu, Bin; Liu, Yang; Chen, Ximeng
作者单位1.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
3.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China
4.Lanzhou Univ, Sch Phys Sci & Technol, Lanzhou 730000, Peoples R China
5.Lanzhou Inst Biol Prod Co Ltd, Lanzhou 730000, Peoples R China
6.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Taofeng,Du, Shaobo,Wang, Yu,et al. Novel Carborane Compounds Based on Cyclooxygenase-2 Inhibitors for Effective Boron Neutron Capture Therapy of Tongue Squamous Cell Carcinoma[J]. CHEMISTRYSELECT,2020,5(46):14652-14660.
APA Zhang, Taofeng.,Du, Shaobo.,Wang, Yu.,Guo, Yanzhu.,Yi, Yangman.,...&Ma, Qianlong.(2020).Novel Carborane Compounds Based on Cyclooxygenase-2 Inhibitors for Effective Boron Neutron Capture Therapy of Tongue Squamous Cell Carcinoma.CHEMISTRYSELECT,5(46),14652-14660.
MLA Zhang, Taofeng,et al."Novel Carborane Compounds Based on Cyclooxygenase-2 Inhibitors for Effective Boron Neutron Capture Therapy of Tongue Squamous Cell Carcinoma".CHEMISTRYSELECT 5.46(2020):14652-14660.

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来源：近代物理研究所

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