Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases
文献类型：期刊论文
| 作者 | Huang, Guomin1,2,3,4,5; Li, Hongyan1,2,3,4,5 ; Zhang, Hong1,2,3,4,5
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2020-11-01 |
| 卷号 | 21期号:22页码:19 |
| 关键词 | mitochondrial ribosome mitochondrial ribosomal proteins apoptosis cancer mitochondrial disease biomarker |
| DOI | 10.3390/ijms21228879 |
| 通讯作者 | Zhang, Hong(zhangh@impcas.ac.cn) |
| 英文摘要 | Mammalian mitochondrial ribosomes translate 13 proteins encoded by mitochondrial genes, all of which play roles in the mitochondrial respiratory chain. After a long period of reconstruction, mitochondrial ribosomes are the most protein-rich ribosomes. Mitochondrial ribosomal proteins (MRPs) are encoded by nuclear genes, synthesized in the cytoplasm and then, transported to the mitochondria to be assembled into mitochondrial ribosomes. MRPs not only play a role in mitochondrial oxidative phosphorylation (OXPHOS). Moreover, they participate in the regulation of cell state as apoptosis inducing factors. Abnormal expressions of MRPs will lead to mitochondrial metabolism disorder, cell dysfunction, etc. Many researches have demonstrated the abnormal expression of MRPs in various tumors. This paper reviews the basic structure of mitochondrial ribosome, focuses on the structure and function of MRPs, and their relationships with cell apoptosis and diseases. It provides a reference for the study of the function of MRPs and the disease diagnosis and treatment. |
| WOS关键词 | DEATH-ASSOCIATED PROTEIN-3 ; BREAST-CANCER ; CRYSTAL-STRUCTURE ; WIDE ASSOCIATION ; CANDIDATE GENES ; FUNCTIONAL-ROLE ; SMALL-SUBUNIT ; MUTATION ; DELETION ; CRIF1 |
| 资助项目 | National Key R&D Program of China[2018YFE0205100] ; National Natural Science Foundation of China[11875061] ; National Natural Science Foundation of China[11505244] ; National Natural Science Foundation of Gansu province[20JR5RA550] ; Key Program of the National Natural Science Foundation of China[U1632270] ; National Laboratory of Heavy ion Accelerator of Lanzhou[E0HIRFL03P] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000594925300001 |
| 出版者 | MDPI |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of Gansu province ; Key Program of the National Natural Science Foundation of China ; National Laboratory of Heavy ion Accelerator of Lanzhou |
| 源URL | [http://119.78.100.186/handle/113462/139346]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Life Sci, Beijing 101408, Peoples R China 2.Adv Energy Sci & Technol Guangdong Lab, Huizhou 516029, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China 4.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 101408, Peoples R China 5.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Guomin,Li, Hongyan,Zhang, Hong. Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(22):19. |
| APA | Huang, Guomin,Li, Hongyan,&Zhang, Hong.(2020).Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(22),19. |
| MLA | Huang, Guomin,et al."Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.22(2020):19. |
入库方式： OAI收割
来源：近代物理研究所
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