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A Minireview on Gastrointestinal Microbiota and Radiosusceptibility

文献类型：期刊论文

作者Mao, Aihong2; Sun, Chao3; Katsube, Takanori1; Wang, Bing1
刊名DOSE-RESPONSE
出版日期2020-10-01
卷号18期号:4页码:11
关键词GI microbiota radiation radiosusceptibility immune response microbiota manipulation
ISSN号1559-3258
DOI10.1177/1559325820963859
通讯作者Mao, Aihong(maoaih@impcas.ac.cn) ; Wang, Bing(wang.bing@qst.go.jp)
英文摘要Gastrointestinal (GI) microbiota maintains a symbiotic relationship with the host and plays a key role in modulating many important biological processes and functions of the host, such as metabolism, inflammation, immune and stress response. It is becoming increasingly apparent that GI microbiota is susceptible to a wide range of environmental factors and insults, for examples, geographic location of birth, diet, use of antibiotics, and exposure to radiation. Alterations in GI microbiota link to various diseases, including radiation-induced disorders. In addition, GI microbiota composition could be used as a biomarker to estimate radiosusceptibility and radiation health risk in the host. In this minireview, we summarized the documented studies on radiation-induced alterations in GI microbiota and the relationship between GI microbiota and radiosusceptibility of the host, and mainly discussed the possible mechanisms underlying GI microbiota influencing the outcome of radiation response in humans and animal models. Furthermore, we proposed that GI microbiota manipulation may be used to reduce radiation injury and improve the health of the host.
资助项目Japan China Medical Association ; Nippon Foundation, Japan
WOS研究方向Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology
语种英语
WOS记录号WOS:000593484200001
出版者SAGE PUBLICATIONS INC
资助机构Japan China Medical Association ; Nippon Foundation, Japan
源URL[http://119.78.100.186/handle/113462/139464]  
专题中国科学院近代物理研究所
通讯作者Mao, Aihong; Wang, Bing
作者单位1.Natl Inst Quantum & Radiol Sci & Technol, Natl Inst Radiol Sci, Chiba, Japan
2.Gansu Prov Acad Inst Med Res, Lanzhou 730050, Peoples R China
3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China
推荐引用方式
GB/T 7714		 Mao, Aihong,Sun, Chao,Katsube, Takanori,et al. A Minireview on Gastrointestinal Microbiota and Radiosusceptibility[J]. DOSE-RESPONSE,2020,18(4):11.
APA Mao, Aihong,Sun, Chao,Katsube, Takanori,&Wang, Bing.(2020).A Minireview on Gastrointestinal Microbiota and Radiosusceptibility.DOSE-RESPONSE,18(4),11.
MLA Mao, Aihong,et al."A Minireview on Gastrointestinal Microbiota and Radiosusceptibility".DOSE-RESPONSE 18.4(2020):11.

入库方式： OAI收割

来源：近代物理研究所

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