Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs)
文献类型：期刊论文
| 作者 | Zhang, Yi-Ming2; Zhang, Li-Ying2; Zhou, Heng1,3 ; Li, Yang-Yang2; Wei, Kong-Xi2; Li, Cheng-Hao2; Zhou, Ting2; Wang, Ju-Fang1,3; Wei, Wen-Jun1,3; Hua, Jun-Rui1,3
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| 刊名 | CELL CYCLE
 |
| 出版日期 | 2020-10-31 |
| 页码 | 13 |
| 关键词 | APS RIBE BMSCs Astragalus Polysaccharide Bystander Effect Apoptosis |
| ISSN号 | 1538-4101 |
| DOI | 10.1080/15384101.2020.1838793 |
| 通讯作者 | Liu, Yong-Qi(liuyongqi73@163.com) |
| 英文摘要 | The purpose of this study was to investigate the effects of astragalus polysaccharides (APS) on the proliferation and apoptosis of bone marrow mesenchymal stem cells (BMSCs) induced by X-ray radiation-induced A549 cells bystander effect (RIBE), and to explore their mechanisms. In this study, APS increased the reduced cell proliferation rate induced by RIBE and inhibiting the apoptosis of bystander cells. In terms of mechanism, APS up-regulates the proteins Bcl-2, Bcl-xl, and down-regulates the proteins Bax and Bak, which induces a decrease in mitochondrial membrane potential, which induces the release of Cyt-c and AIF, which leads to caspase-dependent and caspase-independent pathway to cause apoptosis. In addition, we believe that ROS may be the main cause of these protein changes. APS can inhibit the generation of ROS in bystander cells and thus inhibit the activation of the mitochondrial pathway, further preventing cellular damage caused by RIBE. |
| WOS关键词 | OXIDATIVE STRESS ; X-RAY ; IRRADIATION ; RESPONSES ; SURVIVAL ; THERAPY ; INJURY |
| 资助项目 | National Natural Science Foundation of China[81973595] ; National Natural Science Foundation of China[82004094] ; Collaborative Innovation Project of Chinese and Tibetan Medicine[XBXT2015-1] ; Project of Gansu Provincial Education Department[2015A-095] ; Project of Lanzhou Municipal Science and Technology Bureau[2015-2-48] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000582898300001 |
| 出版者 | TAYLOR & FRANCIS INC |
| 资助机构 | National Natural Science Foundation of China ; Collaborative Innovation Project of Chinese and Tibetan Medicine ; Project of Gansu Provincial Education Department ; Project of Lanzhou Municipal Science and Technology Bureau |
| 源URL | [http://119.78.100.186/handle/113462/139521]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Liu, Yong-Qi |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China 2.Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yi-Ming,Zhang, Li-Ying,Zhou, Heng,et al. Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs)[J]. CELL CYCLE,2020:13. |
| APA | Zhang, Yi-Ming.,Zhang, Li-Ying.,Zhou, Heng.,Li, Yang-Yang.,Wei, Kong-Xi.,...&Liu, Yong-Qi.(2020).Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs).CELL CYCLE,13. |
| MLA | Zhang, Yi-Ming,et al."Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs)".CELL CYCLE (2020):13. |
入库方式： OAI收割
来源：近代物理研究所
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