MicroRNA-29b-3p enhances radiosensitivity through modulating WISP1-mediated mitochondrial apoptosis in prostate cancer cells
文献类型：期刊论文
| 作者 | Mao, Aihong2,3; Tang, Jinzhou2; Tang, Deping4; Wang, Fang3; Liao, Shiqi2; Yuan, Hongxia2; Tian, Caiping2; Sun, Chao3 ; Si, Jing3; Zhang, Hong3
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| 刊名 | JOURNAL OF CANCER
 |
| 出版日期 | 2020 |
| 卷号 | 11期号:21页码:6356-6364 |
| 关键词 | MiR-29b-3p WISP1 radiosensitivity apoptosis prostate cancer |
| ISSN号 | 1837-9664 |
| DOI | 10.7150/jca.48216 |
| 通讯作者 | Zhang, Hong(zhangh@impcas.ac.cn) ; Xia, Xiaojun(xiaxiaojun2006@163.com) |
| 英文摘要 | Radiotherapy is frequently applied for clinically localized prostate cancer while its efficacy could be significantly hindered by radioresistance. MicroRNAs (miRNAs) are important regulators in mediating cellular responses to ionizing radiation (IR), and strongly associate with radiosensitivity in many cancers. In this study, enhancement of radiosensitivity by miR-29b-3p was demonstrated in prostate cancer cell line LNCaP in vitro. Results showed that miR-29b-3p expression was significantly upregulated in response to IR from both X-rays and carbon ion irradiations. Knockdown of miR-29b-3p resulted in radioresistance while overexpression of miR-29b-3p led to increased radiosensitivity (showing reduced cell viability, suppressed cell proliferation and decreased colony formation). In addition, miR-29b-3p was found to directly target Wntl-inducible-signaling protein 1 (WISP]). Inhibition of WISP] facilitated the mitochondrial apoptosis pathway through suppressing Bcl-XL expression while activating caspase-3 and poly (ADP-ribose) polymerase (PARP). The results indicated that miR-29b-3p was a radiosensitizing miRNAs and could enhance radiosensitivity of LNCaP cells by targeting WISP1. These findings suggested a novel treatment to overcome radioresistance in prostate cancer patients, especially those with higher levels of the WISP1 expression. |
| WOS关键词 | MIR-29B ; WISP-1 ; METASTASIS ; ACTIVATION ; EXPRESSION ; RESISTANCE |
| 资助项目 | National Key R&D project of China[2018YFE0205100] ; National Natural Science Foundation of China[11665003] ; Cancer Research Youth Science Foundation of Chinese Anti-Cancer Association[CAYC18A06] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000575093300007 |
| 出版者 | IVYSPRING INT PUBL |
| 资助机构 | National Key R&D project of China ; National Natural Science Foundation of China ; Cancer Research Youth Science Foundation of Chinese Anti-Cancer Association |
| 源URL | [http://119.78.100.186/handle/113462/139705]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong; Xia, Xiaojun |
| 作者单位 | 1.Gansu Prov Canc Hosp, Lanzhou, Peoples R China 2.Gansu Prov Acad Inst Med Res, Lanzhou, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 4.Lanzhou Jiaotong Univ, Sch Chem & Biol Engn, Lanzhou 730070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Aihong,Tang, Jinzhou,Tang, Deping,et al. MicroRNA-29b-3p enhances radiosensitivity through modulating WISP1-mediated mitochondrial apoptosis in prostate cancer cells[J]. JOURNAL OF CANCER,2020,11(21):6356-6364. |
| APA | Mao, Aihong.,Tang, Jinzhou.,Tang, Deping.,Wang, Fang.,Liao, Shiqi.,...&Xia, Xiaojun.(2020).MicroRNA-29b-3p enhances radiosensitivity through modulating WISP1-mediated mitochondrial apoptosis in prostate cancer cells.JOURNAL OF CANCER,11(21),6356-6364. |
| MLA | Mao, Aihong,et al."MicroRNA-29b-3p enhances radiosensitivity through modulating WISP1-mediated mitochondrial apoptosis in prostate cancer cells".JOURNAL OF CANCER 11.21(2020):6356-6364. |
入库方式： OAI收割
来源：近代物理研究所
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