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Multilevel regulation and molecular mechanism of poly (rC)-binding protein 1 in cancer

文献类型：期刊论文

作者Zhang, Xuetian1,2,3,4; Di, Cuixia1,2,3,4; Chen, Yuhong1,2,3,4; Wang, Jing5; Su, Ruowei7; Huang, Guomin1,2,3,4; Xu, Caipeng1,2,3,4; Chen, Xiaohua1,2,3,4; Long, Feng6; Yang, Hongying8
刊名FASEB JOURNAL
出版日期2020-10-15
页码12
ISSN号0892-6638
关键词cancer therapy gene expression mechanisms PCBP1 tumor suppressor
DOI10.1096/fj.202000911R
通讯作者Di, Cuixia(dicx@impcas.ac.cn) ; Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要Poly (rC)-binding protein 1 (PCBP1), an RNA- or DNA-binding protein with a relative molecular weight of 38 kDa, which is characterized by downregulation in many cancer types. Numerous cases have indicated that PCBP1 could be considered as a tumor suppressor to inhibit tumorigenesis, development, and metastasis. In the current review, we described the multilevel regulatory roles of PCBP1, including gene transcription, alternative splicing, and translation of many cancer-related genes. Additionally, we also provided a brief overview about the inhibitory effect of PCBP1 on most common tumors. More importantly, we summarized the current research status about PCBP1 in hypoxic microenvironment, autophagy, apoptosis, and chemotherapy of cancer cells, aiming to clarify the molecular mechanisms of PCBP1 in cancer. Taken together, in-depth study of PCBP1 in cancer may provide new ideas for cancer therapy.
WOS关键词R(C) BINDING-PROTEIN ; NUCLEAR RIBONUCLEOPROTEIN E1 ; RNA-BINDING ; MESSENGER-RNA ; KH-DOMAIN ; STEM-CELLS ; POLY(C)-BINDING PROTEINS ; IN-VITRO ; TRANSLATIONAL REGULATION ; NEGATIVE REGULATOR
资助项目National Key R&D project of the Chinese Ministry of Science and Technology[2018YFE0205100] ; Key Program of the National Natural Science Foundation of China[U1632270] ; National Natural Science Foundation of China[11675234] ; Natural Science Foundation of Gansu Province, China[17JR5RA310]
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
语种英语
出版者WILEY
WOS记录号WOS:000581157600001
资助机构National Key R&D project of the Chinese Ministry of Science and Technology ; Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Gansu Province, China
源URL[http://119.78.100.186/handle/113462/139725]  
专题中国科学院近代物理研究所
通讯作者Di, Cuixia; Zhang, Hong
作者单位1.Chinese Acad Sci, Inst Modern Phys, Biomed Res Ctr, Lanzhou, Gansu, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China
3.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing, Peoples R China
5.Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China
6.Gansu Univ Tradit Chinese Med, Lanzhou, Gansu, Peoples R China
7.Xiamen Univ, Affiliated Hosp 1, Sch Med, Xiamen, Fujian, Peoples R China
8.Med Coll Soochow, Sch Radiat Med & Protect, Suzhou, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xuetian,Di, Cuixia,Chen, Yuhong,et al. Multilevel regulation and molecular mechanism of poly (rC)-binding protein 1 in cancer[J]. FASEB JOURNAL,2020:12.
APA Zhang, Xuetian.,Di, Cuixia.,Chen, Yuhong.,Wang, Jing.,Su, Ruowei.,...&Zhang, Hong.(2020).Multilevel regulation and molecular mechanism of poly (rC)-binding protein 1 in cancer.FASEB JOURNAL,12.
MLA Zhang, Xuetian,et al."Multilevel regulation and molecular mechanism of poly (rC)-binding protein 1 in cancer".FASEB JOURNAL (2020):12.

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来源：近代物理研究所

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