Heat-killedSalmonellaTyphimurium protects mice against carbon ion radiation
文献类型：期刊论文
| 作者 | Liao, Zebin1; Liu, Zhe1; Gong, Zhenyu4; Hu, Xuguang2; Chen, Yuanyuan1; Cao, Kun1; Zhang, Hong3 ; Gan, Lu3; Chen, Juxiang4; Yang, Yanyong1
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| 刊名 | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
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| 出版日期 | 2020-10-01 |
| 卷号 | 48期号:10页码:12 |
| ISSN号 | 0300-0605 |
| 关键词 | Carbon ion radiation heat-killedSalmonellaTyphimurium radioprotector apoptosis IRF3 7 Toll-like receptors |
| DOI | 10.1177/0300060520924256 |
| 通讯作者 | Gan, Lu(ganl@impcas.ac.cn) ; Yang, Yanyong(yyyang2010@163.com) ; Cai, Jianming(cjm882003@163.com) |
| 英文摘要 | Objective Patients receiving carbon-ion radiation therapy and astronauts exploring outer space are inevitably exposed to heavy ion radiation. The aim of this study was to develop radioprotectors to minimize the injuries induced by carbon ion radiation. Methods Heat-killedSalmonellaTyphimurium (HKST) was administered to mice by gavage prior to irradiation with a(12)C(6+)heavy ion accelerator. Hematoxylin and eosin staining and immunofluorescence TdT-mediated dUTP Nick-End Labeling staining were used to assess the radioprotective effect of HKST on organ damage and levels of apoptosis, respectively, in mice. To investigate the mechanism underlying the radioprotective effect of HKST, levels of the pro-apoptotic proteins BAX and caspase 3 as well as interferon-regulatory factor (IRF) 3/7 in the femur, testis and intestine were assessed using immunofluorescence. Results Injuries induced by carbon ion radiation were significantly eased by pretreatment with HKST. Both apoptosis and high expression levels of pro-apoptotic proteins induced by heavy ion radiation were inhibited by HKST pretreatment. The radioprotective effect of HKST was associated with stimulation of Toll-like receptor signaling mediated by enhanced IRF3 and IRF7 signaling. Conclusion HKST was an effective radioprotector alleviating damage to multiple organs caused by heavy ion radiation. |
| WOS关键词 | TYPHIMURIUM ; APOPTOSIS ; RECEPTOR ; CANCER ; LIGANDS ; AGONIST ; DAMAGE |
| 资助项目 | Naval Medical University Medical Protection Project[WL-MS-02] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | SAGE PUBLICATIONS LTD |
| WOS记录号 | WOS:000578351100001 |
| 资助机构 | Naval Medical University Medical Protection Project |
| 源URL | [http://119.78.100.186/handle/113462/139743]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Gan, Lu; Yang, Yanyong; Cai, Jianming |
| 作者单位 | 1.Second Mil Med Univ, Fac Naval Med, Dept Radiat Med, 800 Xiangyin Rd, Shanghai 200433, Peoples R China 2.Changhai Hosp, Dept Gastrointestinal Surg, Shanghai, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 4.Second Mil Med Univ, Changzheng Hosp, Dept Neurosurg, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Zebin,Liu, Zhe,Gong, Zhenyu,et al. Heat-killedSalmonellaTyphimurium protects mice against carbon ion radiation[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2020,48(10):12. |
| APA | Liao, Zebin.,Liu, Zhe.,Gong, Zhenyu.,Hu, Xuguang.,Chen, Yuanyuan.,...&Cai, Jianming.(2020).Heat-killedSalmonellaTyphimurium protects mice against carbon ion radiation.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,48(10),12. |
| MLA | Liao, Zebin,et al."Heat-killedSalmonellaTyphimurium protects mice against carbon ion radiation".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 48.10(2020):12. |
入库方式： OAI收割
来源：近代物理研究所
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