Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment
文献类型：期刊论文
| 作者 | Zhang, Jinhua1,2,3; Si, Jing1,2,3 ; Gan, Lu1,2,3; Zhou, Rong4; Guo, Menghuan5; Zhang, Hong1,2,3
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| 刊名 | JOURNAL OF CELLULAR PHYSIOLOGY
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| 出版日期 | 2020-07-20 |
| 页码 | 17 |
| 关键词 | DNA damage DNA repair particle therapy photon therapy radiosensitizer |
| ISSN号 | 0021-9541 |
| DOI | 10.1002/jcp.29960 |
| 通讯作者 | Si, Jing(sijing@impcas.ac.cn) ; Zhang, Hong(zhangh@impcas.ac.cn) |
| 英文摘要 | Radiotherapy is one of the major modalities for malignancy treatment. High linear energy transfer (LET) charged-particle beams, like proton and carbon ions, exhibit favourable depth-dose distributions and radiobiological enhancement over conventional low-LET photon irradiation, thereby marking a new era in high precision medicine. Tumour cells have developed multicomponent signal transduction networks known as DNA damage responses (DDRs), which initiate cell-cycle checkpoints and induce double-strand break (DSB) repairs in the nucleus by nonhomologous end joining or homologous recombination pathways, to manage ionising radiation (IR)-induced DNA lesions. DNA damage induction and DSB repair pathways are reportedly dependent on the quality of radiation delivered. In this review, we summarise various types of DNA lesion and DSB repair mechanisms, upon irradiation with low and high-LET radiation, respectively. We also analyse factors influencing DNA repair efficiency. Inhibition of DNA damage repair pathways and dysfunctional cell-cycle checkpoint sensitises tumour cells to IR. Radio-sensitising agents, including DNA-PK inhibitors, Rad51 inhibitors, PARP inhibitors, ATM/ATR inhibitors, chk1 inhibitors, wee1 kinase inhibitors, Hsp90 inhibitors, and PI3K/AKT/mTOR inhibitors have been found to enhance cell killing by IR through interference with DDRs, cell-cycle arrest, or other cellular processes. The cotreatment of these inhibitors with IR may represent a promising therapeutic strategy for cancer. |
| WOS关键词 | SQUAMOUS-CELL CARCINOMA ; POLY(ADP-RIBOSE) POLYMERASE INHIBITOR ; DEPENDENT PROTEIN-KINASE ; DOUBLE-STRAND BREAKS ; HUMAN TUMOR-CELLS ; CARBON-ION-BEAMS ; HOMOLOGOUS RECOMBINATION REPAIR ; HUMAN GLIOBLASTOMA CELLS ; INDUCED DNA-DAMAGE ; STEM-LIKE CELLS |
| 资助项目 | National Key R&D Program of China[2018YFE0205100] ; Science and Technology Plan Project of Chengguan district, Lanzhou[2019RCCX0071] ; Lanzhou Talent Innovation and Entrepreneurship Project[2019-RC-76] ; Key Program of the National Natural Science Foundation of China[U1632270] ; CAS Light of West China Program[2018-6] |
| WOS研究方向 | Cell Biology ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000550508600001 |
| 出版者 | WILEY |
| 资助机构 | National Key R&D Program of China ; Science and Technology Plan Project of Chengguan district, Lanzhou ; Lanzhou Talent Innovation and Entrepreneurship Project ; Key Program of the National Natural Science Foundation of China ; CAS Light of West China Program |
| 源URL | [http://119.78.100.186/handle/113462/140237]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Si, Jing; Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 4.Minist Ecol & Environm Peoples Republ China, Nanjing Inst Environm Sci, Res Ctr Ecol Impacts & Environm Hlth Effects Tox, Nanjing, Jiangsu, Peoples R China 5.Lanzhou Univ, Sch Pharm, Lanzhou, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jinhua,Si, Jing,Gan, Lu,et al. Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2020:17. |
| APA | Zhang, Jinhua,Si, Jing,Gan, Lu,Zhou, Rong,Guo, Menghuan,&Zhang, Hong.(2020).Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment.JOURNAL OF CELLULAR PHYSIOLOGY,17. |
| MLA | Zhang, Jinhua,et al."Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment".JOURNAL OF CELLULAR PHYSIOLOGY (2020):17. |
入库方式： OAI收割
来源：近代物理研究所
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