Preliminary study on radiosensitivity to carbon ions in human breast cancer
文献类型：期刊论文
| 作者 | Zhang, Qiuning1,4,5; Kong, Yarong3 ; Yang, Zhen2,5; Liu, Yang4; Liu, Ruifeng1,6; Geng, Yichao1; Luo, Hongtao1,6; Zhang, Hong4; Li, Hongyan4; Feng, Shuangwu1
|
| 刊名 | JOURNAL OF RADIATION RESEARCH
 |
| 出版日期 | 2020-05-01 |
| 卷号 | 61期号:3页码:399-409 |
| 关键词 | carbon ions breast cancer MDA-MB-231 MCF-7 Akt/mTOR/p70S6K pathway radiosensitivity |
| ISSN号 | 0449-3060 |
| DOI | 10.1093/jrr/rraa017 |
| 通讯作者 | Wang, Xiaohu(xhwanggansu@163.com) |
| 英文摘要 | The aim of the study was to investigate the various effects of high linear energy transfer (LET) carbon ion (C-12(6+)) and low LET X-ray radiation on MDA-MB-231 and MCF-7 human breast cancer cells and to explore the underlying mechanisms of radiation sensitivity. Cell proliferation, cell colony formation, cell cycle distribution, cell apoptosis and protein expression levels [double-strand break marker gamma-H2AX, cell cycle-related protein cyclin B1, apoptosis-related proteins Bax and Bcl-2, and the Akt/mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase B1 (p70S6K) pathway] were detected after irradiation with carbon ions or X-rays at doses of 0, 2, 4 and 8 Gy. Our results showed that the inhibition of cell proliferation and cell colony formation and the induction of G(2)/M phase arrest, DNA lesions and cell apoptosis/necrosis elicited by carbon ion irradiation were more potent than the effects elicited by X-ray radiation at the same dose. Simultaneously, compared with X-ray radiation, carbon ion radiation induced a marked increase in Bax and prominent decreases in cyclin B1 and Bcl-2 in a dose-dependent manner. Furthermore, the Akt/mTOR/p70S6K pathway was significantly inhibited by carbon ion radiation in both breast cancer cell lines. These results indicate that carbon ion radiation kills MDA-MB-231 and MCF-7 breast cancer cells more effectively than X-ray radiation, which might result from the inhibition of the Akt/mTOR/p70S6K pathway. |
| WOS关键词 | PI3K/AKT/MTOR SIGNALING PATHWAY ; CELL-CYCLE ; X-RAY ; GROWTH ; PHOSPHORYLATION ; CONTRIBUTES ; RESISTANCE ; INCREASES ; RADIATION ; APOPTOSIS |
| 资助项目 | National Nature Science Foundation of China[81160283 81372419] ; Young creative talents of Gansu project in Gansu Province[[2016] 97] ; Innovative entrepreneurial talent project in Lanzhou[2017RC-23] ; National Natural Science Foundation of China[11575262] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Oncology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000544178000006 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | National Nature Science Foundation of China ; Young creative talents of Gansu project in Gansu Province ; Innovative entrepreneurial talent project in Lanzhou ; National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/140326]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Wang, Xiaohu |
| 作者单位 | 1.Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Basic Med Coll, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Life Sci Coll, Lanzhou 730000, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 5.Lanzhou Heavy Ion Hosp, Lanzhou 730030, Peoples R China 6.Gansu Prov Canc Hosp, Lanzhou 730050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Qiuning,Kong, Yarong,Yang, Zhen,et al. Preliminary study on radiosensitivity to carbon ions in human breast cancer[J]. JOURNAL OF RADIATION RESEARCH,2020,61(3):399-409. |
| APA | Zhang, Qiuning.,Kong, Yarong.,Yang, Zhen.,Liu, Yang.,Liu, Ruifeng.,...&Wang, Xiaohu.(2020).Preliminary study on radiosensitivity to carbon ions in human breast cancer.JOURNAL OF RADIATION RESEARCH,61(3),399-409. |
| MLA | Zhang, Qiuning,et al."Preliminary study on radiosensitivity to carbon ions in human breast cancer".JOURNAL OF RADIATION RESEARCH 61.3(2020):399-409. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。