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The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance

文献类型：期刊论文

作者Du, Yarong2,3,4; Pan, Dong3,4; Jia, Rong1,3,4; Chen, Yaxiong3,4; Jia, Cong2; Wang, Jufang1,3,4; Hu, Burong1,3,4
刊名OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
出版日期2020-03-04
卷号2020页码:12
ISSN号1942-0900
DOI10.1155/2020/2167129
通讯作者Hu, Burong(hubr@impcas.ac.cn)
英文摘要Although the mitochondrial antiviral signaling protein (MAVS), located in the mitochondrial outmembrane, is believed to be a signaling adaptor with antiviral feature firstly, it has been shown that suppression of MAVS enhanced radioresistance. The mechanisms underlying this radioresistance remain unclear. Our current study demonstrated that knockdown of MAVS alleviated the radiation-induced mitochondrial dysfunction (mitochondrial membrane potential disruption and ATP production), downregulated the expressions of proapoptotic proteins, and reduced the generation of ROS in cells after irradiation. Furthermore, inhibition of mitochondrial ROS by the mitochondria-targeted antioxidant MitoQ reduced amounts of oligomerized MAVS after irradiation compared with the control group and also prevented the incidence of MN and increased the survival fraction of normal A549 cells after irradiation. To our knowledge, it is the first report to indicate that MAVS, an innate immune signaling molecule, is involved in radiation response via its oligomerization mediated by radiation-induced ROS, which may be a potential target for the precise radiotherapy or radioprotection.
WOS关键词ANTITUMOR IMMUNITY ; CANCER CELLS ; RADIATION ; MITOCHONDRIA ; IRRADIATION ; EXPRESSION ; INDUCTION ; AUTOPHAGY ; EXPOSURE ; RELEASE
资助项目National Natural Science Foundation of China[11635013] ; National Natural Science Foundation of China[11705248] ; National Natural Science Foundation of China[U1632145] ; National Key Research and Development Program of China[2017YFC0108605] ; Science and Technology Research Project of Gansu Province[145RTSA012] ; Science and Technology Research Project of Gansu Province[17JR5RA307]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000522268000006
出版者HINDAWI LTD
资助机构National Natural Science Foundation of China ; National Key Research and Development Program of China ; Science and Technology Research Project of Gansu Province
源URL[http://119.78.100.186/handle/113462/140599]  
专题中国科学院近代物理研究所
通讯作者Hu, Burong
作者单位1.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 100039, Peoples R China
2.Northwest Normal Univ, Coll Life Sci, Lanzhou 730070, Peoples R China
3.Chinese Acad Sci, Inst Modern Phys, CAS Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
4.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Du, Yarong,Pan, Dong,Jia, Rong,et al. The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2020,2020:12.
APA Du, Yarong.,Pan, Dong.,Jia, Rong.,Chen, Yaxiong.,Jia, Cong.,...&Hu, Burong.(2020).The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2020,12.
MLA Du, Yarong,et al."The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2020(2020):12.

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来源：近代物理研究所

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