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The MDM2/MDMX/p53 axis in the adaptive stress response

文献类型：期刊论文

作者Wang, Bing1,2,3,4; Rasmussen-Ivey, Cody4; Little, John B.4; Yuan, Zhi-Min4
刊名TRANSLATIONAL CANCER RESEARCH
出版日期2020-03-01
卷号9期号:3页码:1993-1997
关键词The MDM2/MDMX/p53 axis mild stress adaptive stress response cell fate
ISSN号2218-676X
DOI10.21037/tcr.2019.12.89
通讯作者Yuan, Zhi-Min(zyuan@hsph.harvard.edu)
英文摘要Via regulation of cellular stress responses, p53 contributes to the maintenance of homeostasis. Contrary to its well-established pro-death function, p53 is also implicated in promoting cell survival by mediating the adaptive stress response. Emerging data reveal that the adaptive stress response is coupled with p53 decline that is a prerequisite for the induction of pro-survival pathways augmenting cell fitness. However, if the adaptive stress responses persist or become chronic, the sustained p53 downregulation would result in a permanent loss of p53 function and p53-dependent homeostasis. The available information suggests a model in which cells respond to different levels of stress by governing the activity and abundance of p53 that, in turn, determines the cell fate dependent on not only the intensity but also the duration of stress.
WOS关键词EMBRYONIC LETHALITY ; P53 ACTIVITY ; MDM2-DEFICIENT MICE ; SUPPRESSES P53 ; MDM2 ; RESCUE ; STABILIZATION ; COMPLEX
资助项目Morningside Foundation ; National Cancer Institute at the National Institutes of Health[R01CA233558] ; National Cancer Institute at the National Institutes of Health[R01CA167814] ; National Cancer Institute at the National Institutes of Health[R01CA125144]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000522761900070
出版者AME PUBL CO
资助机构Morningside Foundation ; National Cancer Institute at the National Institutes of Health
源URL[http://119.78.100.186/handle/113462/140650]  
专题中国科学院近代物理研究所
通讯作者Yuan, Zhi-Min
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Peoples R China
3.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
4.Harvard TH Chan Sch Publ Hlth, John B Little Ctr Radiat Sci, Boston, MA 02115 USA
推荐引用方式
GB/T 7714		 Wang, Bing,Rasmussen-Ivey, Cody,Little, John B.,et al. The MDM2/MDMX/p53 axis in the adaptive stress response[J]. TRANSLATIONAL CANCER RESEARCH,2020,9(3):1993-1997.
APA Wang, Bing,Rasmussen-Ivey, Cody,Little, John B.,&Yuan, Zhi-Min.(2020).The MDM2/MDMX/p53 axis in the adaptive stress response.TRANSLATIONAL CANCER RESEARCH,9(3),1993-1997.
MLA Wang, Bing,et al."The MDM2/MDMX/p53 axis in the adaptive stress response".TRANSLATIONAL CANCER RESEARCH 9.3(2020):1993-1997.

入库方式： OAI收割

来源：近代物理研究所

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