Perturbation analysis of 4D dose distribution for scanned carbon-ion beam radiotherapy
文献类型：期刊论文
| 作者 | He, Pengbo1,2,3 ; Mori, Shinichiro2
|
| 刊名 | PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
 |
| 出版日期 | 2020-06-01 |
| 卷号 | 74页码:74-82 |
| 关键词 | Carbon-ion radiotherapy Patient set-up Perturbation analysis 4D dose distribution |
| ISSN号 | 1120-1797 |
| DOI | 10.1016/j.ejmp.2020.05.003 |
| 通讯作者 | He, Pengbo(hepengbo@impcas.ac.cn) |
| 英文摘要 | Purpose: To evaluate the patients' set-up error-induced perturbation effects on 4D dose distributions (4DDD) of range-adapted internal target volume-based (raITV) treatment plan using lung and liver 4DCT data sets. Methods: We enrolled 20 patients with lung and liver cancer treated with respiratory-gated carbon-ion beam scanning therapy. PTVs were generated by adding a 2 mm range-adapted set-up margin on the raITVs. Set-up errors were simulated by shifting the beam isocenter in three translational directions of +/- 2 mm, +/- 4 mm, and +/- 6 mm. 4DDDs were calculated for both nominal and isocenter-shifted situations. Dose metrics of CTV dose coverage (D95) and normal tissue sparing were evaluated. Statistical significance with p < 0.01 was considered by Wilcoxon signed rank test. Results: The CTV dose coverage was more sensitive to set-up errors for lung cases than for liver cases, and more serious in superior-inferior direction. The sufficient CTV-D95 > 98% could be achieved with set-up errors less than +/- 2 mm in all shift directions both for lung and liver cases. With the increase of set-up error, the CTV dose coverage decreased gradually. The clinical criterial of CTV-D95 > 95% could not be fulfilled with set-up error reached to +/- 4 mm for lung cases, and +/- 6 mm for liver cases. OAR doses did not have a significant difference with each set-up error for both lung and liver cases. Conclusions: The range-adapted set-up margin successfully prevented dose degradation of 4DDDs in the presence of the same magnitude of set-up error for raITV-based carbon-ion beam scanning therapy. |
| WOS关键词 | PROTON THERAPY ; RESPIRATORY MOTION ; PARTICLE THERAPY ; IRRADIATION ; SYSTEM ; CT ; LUNG ; REPRODUCIBILITY ; OPTIMIZATION ; INTERPLAY |
| 资助项目 | National Natural Science Foundation of China[11705247] ; Youth Innovation Promotion Association, Chinese Academy of Sciences, China[2019405] ; Chinese Academy of Sciences Scholarship, China[201885] |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000537810100009 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences, China ; Chinese Academy of Sciences Scholarship, China |
| 源URL | [http://119.78.100.186/handle/113462/140773]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | He, Pengbo |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Peoples R China 2.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Chiba, Japan 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Pengbo,Mori, Shinichiro. Perturbation analysis of 4D dose distribution for scanned carbon-ion beam radiotherapy[J]. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,2020,74:74-82. |
| APA | He, Pengbo,&Mori, Shinichiro.(2020).Perturbation analysis of 4D dose distribution for scanned carbon-ion beam radiotherapy.PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,74,74-82. |
| MLA | He, Pengbo,et al."Perturbation analysis of 4D dose distribution for scanned carbon-ion beam radiotherapy".PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 74(2020):74-82. |
入库方式： OAI收割
来源：近代物理研究所
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