A beta-allyl carbamate fluorescent probe for vicinal dithiol proteins
文献类型：期刊论文
| 作者 | Zhao, Lanning1; Bai, Feifei1; Chen, Fan1; Guo, Menghuan2; Gan, Lu3,4,5 ; Zhang, Hong3,4,5; Fang, Jianguo1
|
| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2020-03-07 |
| 卷号 | 56期号:19页码:2857-2860 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c9cc09841k |
| 通讯作者 | Fang, Jianguo(fangjg@lzu.edu.cn) |
| 英文摘要 | The first beta-allyl carbamate fluorescent probe, AC-green, was reported for specifically imaging vicinal dithiol proteins (VDPs) in living systems. The probe displays low toxicity and features high sensitivity and fast response towards VDPs. A drastic loss of VDPs in a Parkinson's model was disclosed by AC-green, linking the fluctuation of VDP levels to Parkinson's disease for the first time. The structural novelty and favorable properties of AC-green will advance the development of novel VDP probes. |
| WOS关键词 | THIOREDOXIN REDUCTASE ; FLUOROGENS ; DISCOVERY ; DESIGN |
| 资助项目 | National Natural Science Foundation of China[21778028] ; National Natural Science Foundation of China[21572093] ; Ministry of Science and Technology National Key RD Project[2018YFE0205100] ; Natural Science Foundation of Gansu Province[18JR4RA003] ; 111 project |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000519216400004 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China ; Ministry of Science and Technology National Key RD Project ; Natural Science Foundation of Gansu Province ; 111 project |
| 源URL | [http://119.78.100.186/handle/113462/140939]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Fang, Jianguo |
| 作者单位 | 1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Gansu, Peoples R China 4.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Lanning,Bai, Feifei,Chen, Fan,et al. A beta-allyl carbamate fluorescent probe for vicinal dithiol proteins[J]. CHEMICAL COMMUNICATIONS,2020,56(19):2857-2860. |
| APA | Zhao, Lanning.,Bai, Feifei.,Chen, Fan.,Guo, Menghuan.,Gan, Lu.,...&Fang, Jianguo.(2020).A beta-allyl carbamate fluorescent probe for vicinal dithiol proteins.CHEMICAL COMMUNICATIONS,56(19),2857-2860. |
| MLA | Zhao, Lanning,et al."A beta-allyl carbamate fluorescent probe for vicinal dithiol proteins".CHEMICAL COMMUNICATIONS 56.19(2020):2857-2860. |
入库方式： OAI收割
来源：近代物理研究所
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