Radioprotective effect of orally administered beta-D-glucan derived from Saccharomyces cerevisiae
文献类型：期刊论文
| 作者 | Liu, Fang1,2; Wang, Zhuanzi1 ; Liu, Jia3; Li, Wenjian1
|
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 115页码:572-579 |
| 关键词 | Saccharomyces cerevisiae-derived-beta-D-glucan Radioprotective effect Protective mechanism |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2018.04.098 |
| 通讯作者 | Wang, Zhuanzi(wangzz@impcas.ac.cn) |
| 英文摘要 | The present study was to evaluate the in vivo radioprotective effect of oral administration of Saccharomyces cerevisiae-derived-beta-D-glucan (S. cerevisiae-BG) and to investigate the protective mechanism. The results demonstrated that oral pretreatment with 350 mg/kg S. cerevisiae-BG once daily for 14 consecutive days significantly increased the survival rate of mice from 6 Gy X-rays irradiation. At the 30th day after irradiation, cellularity and the percentage of hematopoietic stem/progenitor cells in bone marrow (BM) of surviving mice were increased by S. cerevisiae-BG. Further studies showed that S. cerevisiae-BG decreased BM cell DNA damage and improved BM cell cycle progress in irradiated mice. And the reactive oxygen species (ROS) levels in BM cells of irradiated mice were also decreased by S. cerevisiae-BG. These results indicated that oral S. cerevisiae-BG exhibited obviously radioprotective effect in mice and the protective effect may be attributed to the polysaccharide's hema-topoiesis-modulating action and free radical scavenging property. S. cerevisiae-BG protects BM cells from radiation damage through scavenging BM cell ROS, mitigating BM cell DNA damage and improving cell cycle progress, and thus mitigated myelosuppression induced by irradiation and stimulated hematopoiesis, ultimately increased the survival of radiated mice. (C) 2018 Published by Elsevier B.V. |
| WOS关键词 | HEMATOPOIETIC STEM-CELLS ; BONE-MARROW INJURY ; GAMMA-IRRADIATION ; OXIDATIVE STRESS ; DNA-DAMAGE ; MICE ; CARBOXYMETHYLGLUCAN ; YEAST ; POLYSACCHARIDES ; RECOVERY |
| 资助项目 | National Natural Science Foundation of China[NSFC 11575259] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000438662500065 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/141131]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Wang, Zhuanzi |
| 作者单位 | 1.Chinese Acad Sci, Inst Modem Phys, Lanzhou 730000, Gansu, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Fang,Wang, Zhuanzi,Liu, Jia,et al. Radioprotective effect of orally administered beta-D-glucan derived from Saccharomyces cerevisiae[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,115:572-579. |
| APA | Liu, Fang,Wang, Zhuanzi,Liu, Jia,&Li, Wenjian.(2018).Radioprotective effect of orally administered beta-D-glucan derived from Saccharomyces cerevisiae.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,115,572-579. |
| MLA | Liu, Fang,et al."Radioprotective effect of orally administered beta-D-glucan derived from Saccharomyces cerevisiae".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 115(2018):572-579. |
入库方式： OAI收割
来源：近代物理研究所
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