Selective imaging of analytes in living cells and zebrafish using a novel peptide-based fluorescence chemosensor with different responses
文献类型：期刊论文
| 作者 | Li, Yongxin1,2; Di, Cuixia4 ; Wu, Jiang1,2,3,5; Si, Jing4; Zhang, Qianjing4; Zhang, Hong4; Ge, Yushu5; Liu, Dan5; Liu, Weisheng1,2
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| 刊名 | MICROCHEMICAL JOURNAL
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| 出版日期 | 2019-11-01 |
| 卷号 | 150页码:8 |
| 关键词 | Peptide backbone Fluorescence chemosensor Cell imaging Zebrafish imaging |
| ISSN号 | 0026-265X |
| DOI | 10.1016/j.microc.2019.104182 |
| 通讯作者 | Wu, Jiang(wujiang@lzu.edu.cn) ; Liu, Weisheng(liuws@lzu.edu.cn) |
| 英文摘要 | Monitoring and imaging the requirements of heavy metal ions in organisms are very strict, so biologists and chemists wishfully expect powerful probes to achieve. Herein, DnsP has been successfully designed and synthesized using a highly biocompatible and low biotoxic peptide backbone as an ionophore to selectively detect Zn2+ and Cu2+ in aqueous solution in different response modes. In addition, the DnsP-Cu2+ system has high selectivity for H2S and can restore the fluorescence of DnsP for the detection of S2-. Finally, DnsP demonstrated excellent cell permeation and low biological toxicity for biosensing in cellular and zebrafish. Therefore, DnsP represents a prominent peptide fluorescence chemosensor, capable of multifunctional analyte detection and continuous response imaging in environmental and biological systems. |
| WOS关键词 | HEAVY-METAL IONS ; SENSITIVE DETECTION ; QUANTUM DOTS ; COPPER ; PROBE ; SENSOR ; ZINC ; CHEMISTRY ; BIOLOGY ; CU2+ |
| 资助项目 | Major State Special Research Project of China[2016YFA0101200] ; Major State Basic Research Development Program of China (973 Program)[2015CB553701] ; Major Program of National Natural Science Foundation of China[91749125] ; National Natural Science Foundation of China (NSFC)[21778050] ; National Natural Science Foundation of China (NSFC)[11675234] ; National Natural Science Foundation of China (NSFC)[21201091] ; Natural Science Foundation of Gansu Province[17JR5RA310] ; Key Program of the National Natural Science Foundation of China[U1632270] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000495469400103 |
| 出版者 | ELSEVIER |
| 资助机构 | Major State Special Research Project of China ; Major State Basic Research Development Program of China (973 Program) ; Major Program of National Natural Science Foundation of China ; National Natural Science Foundation of China (NSFC) ; Natural Science Foundation of Gansu Province ; Key Program of the National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/141550]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Wu, Jiang; Liu, Weisheng |
| 作者单位 | 1.Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Gansu, Peoples R China 5.Univ Sci & Technol China, Collaborat Innovat Ctr Chem Life Sci, Sch Life Sci, Hefei 230027, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yongxin,Di, Cuixia,Wu, Jiang,et al. Selective imaging of analytes in living cells and zebrafish using a novel peptide-based fluorescence chemosensor with different responses[J]. MICROCHEMICAL JOURNAL,2019,150:8. |
| APA | Li, Yongxin.,Di, Cuixia.,Wu, Jiang.,Si, Jing.,Zhang, Qianjing.,...&Liu, Weisheng.(2019).Selective imaging of analytes in living cells and zebrafish using a novel peptide-based fluorescence chemosensor with different responses.MICROCHEMICAL JOURNAL,150,8. |
| MLA | Li, Yongxin,et al."Selective imaging of analytes in living cells and zebrafish using a novel peptide-based fluorescence chemosensor with different responses".MICROCHEMICAL JOURNAL 150(2019):8. |
入库方式： OAI收割
来源：近代物理研究所
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