Radiation-induced lung injury: latest molecular developments, therapeutic approaches, and clinical guidance
文献类型：期刊论文
| 作者 | Lu, Lina1,2; Sun, Chao3 ; Su, Qiong1,2; Wang, Yanbin1,2; Li, Jia1,2; Guo, Zhong4; Chen, Lihua1,2; Zhang, Hong3
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| 刊名 | CLINICAL AND EXPERIMENTAL MEDICINE
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| 出版日期 | 2019-11-01 |
| 卷号 | 19期号:4页码:417-426 |
| 关键词 | Cancer Lung Radiation pneumonitis Fibrosis Radiation Therapy |
| ISSN号 | 1591-8890 |
| DOI | 10.1007/s10238-019-00571-w |
| 通讯作者 | Chen, Lihua(lihuachen_clh@outlook.com) ; Zhang, Hong(zhangh@impcas.ac.cn) |
| 英文摘要 | Cancer research has advanced throughout the years with respect to the personalization of the treatments and to targeting cancer-related molecular signatures on different organs. Still, the adverse events of the treatments such as radiotherapy are of high concern as they may increase the mortality rate due to their severity. With the improved efficiency of cancer treatments, patient survival has been increasing. Consequently, the number of patients with adverse effects from radiotherapy is also expected to increase in the forthcoming years. Therefore, approaches for personalized treatments include the elimination of adverse events and decreasing the toxicity in healthy tissues while increasing the efficiency of cancer cytotoxicity. In this context, this paper aims to discuss the recent advances in the field of thorax irradiation therapy and its related toxicities leading to radiation pneumonitis in cancer patients. Molecular mechanisms involved in the radiation-induced lung injury and approaches used to overcome this lung injury are discussed. The discourse covers approaches such as therapeutic administration of natural products, current and prospective radioprotective drugs, and applications of mesenchymal stem cells for radiation-induced lung injury. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; IONIZING-RADIATION ; MELATONIN ; PNEUMONITIS ; TRIALS ; RADIOTHERAPY ; INHIBITION ; TOXICITY |
| 资助项目 | Innovation and Entrepreneurship Talent Project of Lanzhou[2018-RC-81] ; National Natural Science Foundation of China[81560508] ; National Natural Science Foundation of China[51563022] ; Fundamental Research Funds for the Central Universities[31920180020] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000491035600002 |
| 出版者 | SPRINGER-VERLAG ITALIA SRL |
| 资助机构 | Innovation and Entrepreneurship Talent Project of Lanzhou ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://119.78.100.186/handle/113462/141742]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Chen, Lihua; Zhang, Hong |
| 作者单位 | 1.Northwest Minzu Univ, Chem Engn Inst, Lanzhou 730000, Gansu, Peoples R China 2.Key Lab Util Environm Friendly Composite Mat & Bi, Lanzhou 730124, Gansu, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 4.Northwest Minzu Univ, Med Coll, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Lina,Sun, Chao,Su, Qiong,et al. Radiation-induced lung injury: latest molecular developments, therapeutic approaches, and clinical guidance[J]. CLINICAL AND EXPERIMENTAL MEDICINE,2019,19(4):417-426. |
| APA | Lu, Lina.,Sun, Chao.,Su, Qiong.,Wang, Yanbin.,Li, Jia.,...&Zhang, Hong.(2019).Radiation-induced lung injury: latest molecular developments, therapeutic approaches, and clinical guidance.CLINICAL AND EXPERIMENTAL MEDICINE,19(4),417-426. |
| MLA | Lu, Lina,et al."Radiation-induced lung injury: latest molecular developments, therapeutic approaches, and clinical guidance".CLINICAL AND EXPERIMENTAL MEDICINE 19.4(2019):417-426. |
入库方式： OAI收割
来源：近代物理研究所
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